Literature DB >> 17620083

Importance of 5-hydroxytryptamine receptors on intestinal afferents in the regulation of visceral sensitivity.

B Greenwood-van Meerveld1.   

Abstract

Serotonin (5-HT) plays an important role as a signalling molecule in the gastrointestinal (GI) tract. The regulation of GI sensitivity via 5-HT is mediated by specific 5-HT receptor subytypes on intrinsic and extrinsic afferents. This review discusses visceral afferent hypersensitivity in irritable bowel syndrome (IBS) and the importance of 5HT(3), 5HT(4), and 5HT(2B) receptor-mediated mechanisms in the regulation of visceral sensitivity.

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Year:  2007        PMID： 17620083     DOI： 10.1111/j.1365-2982.2007.00964.x

Source DB:  PubMed          Journal:  Neurogastroenterol Motil        ISSN： 1350-1925            Impact factor:   3.598


  16 in total

1.  Visceral analgesic effect of 5-HT(4) receptor agonist in rats involves the rostroventral medulla (RVM).

Authors:  Jyoti N Sengupta; Aaron Mickle; Pradeep Kannampalli; Russell Spruell; John McRorie; Reza Shaker; Adrian Miranda
Journal:  Neuropharmacology       Date:  2013-12-12       Impact factor: 5.250

Review 2.  Irritable bowel syndrome: a microbiome-gut-brain axis disorder?

Authors:  Paul J Kennedy; John F Cryan; Timothy G Dinan; Gerard Clarke
Journal:  World J Gastroenterol       Date:  2014-10-21       Impact factor: 5.742

Review 3.  Mechanisms underlying visceral hypersensitivity in irritable bowel syndrome.

Authors:  Giovanni Barbara; Cesare Cremon; Roberto De Giorgio; Giovanni Dothel; Lisa Zecchi; Lara Bellacosa; Giovanni Carini; Vincenzo Stanghellini; Roberto Corinaldesi
Journal:  Curr Gastroenterol Rep       Date:  2011-08

Review 4.  Ion channels, ion channel receptors, and visceral hypersensitivity in irritable bowel syndrome.

Authors:  I M Fuentes; J A Christianson
Journal:  Neurogastroenterol Motil       Date:  2016-11       Impact factor: 3.598

Review 5.  Visceral pain: the neurophysiological mechanism.

Authors:  Jyoti N Sengupta
Journal:  Handb Exp Pharmacol       Date:  2009

Review 6.  Updates on treatment of irritable bowel syndrome.

Authors:  Christopher W Hammerle; Christina M Surawicz
Journal:  World J Gastroenterol       Date:  2008-05-07       Impact factor: 5.742

7.  An Evidence-based Approach to Therapy in IBS-D: A Case Study Compendium.

Authors:  Lin Chang; Brian E Lacy; Brennan M R Spiegel
Journal:  Gastroenterol Hepatol (N Y)       Date:  2010-09

8.  JCM-16021, a Chinese Herbal Formula, Attenuated Visceral Hyperalgesia in TNBS-Induced Postinflammatory Irritable Bowel Syndrome through Reducing Colonic EC Cell Hyperplasia and Serotonin Availability in Rats.

Authors:  Hong-Yan Qin; Hai-Tao Xiao; Fung-Ping Leung; Zhi-Jun Yang; Justin C Y Wu; Joseph J Y Sung; Hong-Xi Xu; Xu-Dong Tong; Zhao-Xiang Bian
Journal:  Evid Based Complement Alternat Med       Date:  2012-06-10       Impact factor: 2.629

Review 9.  Main ion channels and receptors associated with visceral hypersensitivity in irritable bowel syndrome.

Authors:  Heraldo Arcela de Carvalho Rocha; Bruna Priscilla Vasconcelos Dantas; Thaísa Leite Rolim; Bagnólia Araújo Costa; Arnaldo Correia de Medeiros
Journal:  Ann Gastroenterol       Date:  2014

10.  Sensory Adaptation Training or Escitalopram for IBS With Constipation and Rectal Hypersensitivity: A Randomized Controlled Trial.

Authors:  Satish S C Rao; Enrique Coss-Adame; Yun Yan; Askin Erdogan; Jessica Valestin; Deepak Nag Ayyala
Journal:  Clin Transl Gastroenterol       Date:  2021-07-13       Impact factor: 4.488
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