Literature DB >> 17619957

Melt flow behaviour of poly-epsilon-caprolactone in fused deposition modelling.

H S Ramanath1, C K Chua, K F Leong, K D Shah.   

Abstract

Fused deposition modelling (FDM) is an extrusion based Rapid prototyping (RP) technique which can be used to fabricate tissue engineering scaffolds. The present work focuses on the study of the melt flow behaviour (MFB) of Poly-epsilon-caprolactone (PCL) as a representative biomaterial, on the FDM. The MFB significantly affects the quality of the scaffold which depends not only on the pressure gradient, its velocity, and the temperature gradients but also physical properties like the melt temperature and rheology. The MFB is studied using two methods: mathematical modelling and finite element analysis (FEA) using Ansys(R). The MFB is studied using accurate channel geometry by varying filament velocity at the entry and by varying nozzle diameters and angles at the exit. The comparative results of both mathematical modelling and FEA suggest that the pressure drop and the velocities of the melt flow depend on the flow channel parameters. One inference of particular interest is the temperature gradient of the PCL melt, which shows that it liquefies within 35% of the channel length. These results are invaluable to better understand the MFB of biomaterials that affects the quality of the scaffold built via FDM and can also be used to predict the MFB of other biomaterials.

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Year:  2007        PMID: 17619957     DOI: 10.1007/s10856-007-3203-6

Source DB:  PubMed          Journal:  J Mater Sci Mater Med        ISSN: 0957-4530            Impact factor:   3.896


  9 in total

1.  Fused deposition modeling of novel scaffold architectures for tissue engineering applications.

Authors:  Iwan Zein; Dietmar W Hutmacher; Kim Cheng Tan; Swee Hin Teoh
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Review 2.  The design of scaffolds for use in tissue engineering. Part I. Traditional factors.

Authors:  S Yang; K F Leong; Z Du; C K Chua
Journal:  Tissue Eng       Date:  2001-12

Review 3.  The design of scaffolds for use in tissue engineering. Part II. Rapid prototyping techniques.

Authors:  Shoufeng Yang; Kah-Fai Leong; Zhaohui Du; Chee-Kai Chua
Journal:  Tissue Eng       Date:  2002-02

Review 4.  Solid freeform fabrication of three-dimensional scaffolds for engineering replacement tissues and organs.

Authors:  K F Leong; C M Cheah; C K Chua
Journal:  Biomaterials       Date:  2003-06       Impact factor: 12.479

5.  3D microtomographic characterization of precision extruded poly-epsilon-caprolactone scaffolds.

Authors:  A L Darling; W Sun
Journal:  J Biomed Mater Res B Appl Biomater       Date:  2004-08-15       Impact factor: 3.368

Review 6.  Rapid prototyping in tissue engineering: challenges and potential.

Authors:  Wai-Yee Yeong; Chee-Kai Chua; Kah-Fai Leong; Margam Chandrasekaran
Journal:  Trends Biotechnol       Date:  2004-12       Impact factor: 19.536

7.  Compressive properties and degradability of poly(epsilon-caprolatone)/hydroxyapatite composites under accelerated hydrolytic degradation.

Authors:  K C Ang; K F Leong; C K Chua; M Chandrasekaran
Journal:  J Biomed Mater Res A       Date:  2007-03-01       Impact factor: 4.396

8.  Fabrication of biodegradable polymer scaffolds to engineer trabecular bone.

Authors:  R C Thomson; M J Yaszemski; J M Powers; A G Mikos
Journal:  J Biomater Sci Polym Ed       Date:  1995       Impact factor: 3.517

9.  Innovative tissue engineering structures through advanced manufacturing technologies.

Authors:  Gianluca Ciardelli; Valeria Chiono; Caterina Cristallini; Niccoletta Barbani; Arti Ahluwalia; Giovanni Vozzi; Antonino Previti; Giovanni Tantussi; Paolo Giusti
Journal:  J Mater Sci Mater Med       Date:  2004-04       Impact factor: 3.896

  9 in total
  11 in total

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Journal:  Chem Rev       Date:  2017-07-30       Impact factor: 60.622

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Authors:  George Z Cheng; Raul San Jose Estepar; Erik Folch; Jorge Onieva; Sidhu Gangadharan; Adnan Majid
Journal:  Chest       Date:  2016-03-12       Impact factor: 9.410

3.  Immediate Release 3D-Printed Tablets Produced Via Fused Deposition Modeling of a Thermo-Sensitive Drug.

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Review 4.  Microfabricated biomaterials for engineering 3D tissues.

Authors:  Pinar Zorlutuna; Nasim Annabi; Gulden Camci-Unal; Mehdi Nikkhah; Jae Min Cha; Jason W Nichol; Amir Manbachi; Hojae Bae; Shaochen Chen; Ali Khademhosseini
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5.  Chondrogenic regeneration using bone marrow clots and a porous polycaprolactone-hydroxyapatite scaffold by three-dimensional printing.

Authors:  Qingqiang Yao; Bo Wei; Nancy Liu; Chenshuang Li; Yang Guo; Arya Nick Shamie; James Chen; Cheng Tang; Chengzhe Jin; Yan Xu; Xiuwu Bian; Xinli Zhang; Liming Wang
Journal:  Tissue Eng Part A       Date:  2015-04       Impact factor: 3.845

6.  Strategic design and fabrication of engineered scaffolds for articular cartilage repair.

Authors:  Zohreh Izadifar; Xiongbiao Chen; William Kulyk
Journal:  J Funct Biomater       Date:  2012-11-14

7.  An Investigation of the Behavior of Solvent based Polycaprolactone ink for Material Jetting.

Authors:  Yinfeng He; Ricky D Wildman; Chris J Tuck; Steven D R Christie; Steven Edmondson
Journal:  Sci Rep       Date:  2016-02-12       Impact factor: 4.379

Review 8.  Bone tissue engineering scaffolding: computer-aided scaffolding techniques.

Authors:  Boonlom Thavornyutikarn; Nattapon Chantarapanich; Kriskrai Sitthiseripratip; George A Thouas; Qizhi Chen
Journal:  Prog Biomater       Date:  2014-07-17

9.  Development of a Three-Dimensional Bioengineered Platform for Articular Cartilage Regeneration.

Authors:  Gerard Rubí-Sans; Lourdes Recha-Sancho; Soledad Pérez-Amodio; Miguel Ángel Mateos-Timoneda; Carlos Eduardo Semino; Elisabeth Engel
Journal:  Biomolecules       Date:  2019-12-28

10.  Rheological Investigation of Hydroxypropyl Cellulose-Based Filaments for Material Extrusion 3D Printing.

Authors:  Yee Mon Than; Sarisa Suriyarak; Varin Titapiwatanakun
Journal:  Polymers (Basel)       Date:  2022-03-10       Impact factor: 4.329

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