Literature DB >> 17619108

Neurosarcoidosis presenting as a cerebellar mass.

Gautam Kumar1, Caroline A Kang, Caterina Giannini.   

Abstract

CASE REPORT: A 74-year-old farmer presented with worsening headaches, gait unsteadiness, and writing difficulties. On examination, he had a tendency to fall to the right and right-sided dysmetria and dysdiadochokinesis. Magnetic resonance imaging initially showed abnormalities in the right cerebellar hemisphere, suggestive of subacute infarct or infiltrating malignancy. Suboccipital craniotomy and biopsy revealed noncaseating granulomas suggestive of sarcoidosis. He was initially treated with steroids and later switched to Infliximab. On follow-up 5 months later, symptoms and imaging had improved. DISCUSSION: Sarcoidosis affects the central nervous system in about 5% of patients. It usually manifests with cranial nerve palsies. It may rarely mimic a tumor as in this patient. Despite the dearth of controlled studies addressing neurosarcoidosis treatment, excellent responses to corticosteroids have been documented. Infliximab has been used as a steroid-sparing agent in neurosarcoidosis. We present this case of neurosarcoidosis presenting as a cerebellar mass to increase awareness of this condition.

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Year:  2007        PMID: 17619108      PMCID: PMC2219770          DOI: 10.1007/s11606-007-0272-7

Source DB:  PubMed          Journal:  J Gen Intern Med        ISSN: 0884-8734            Impact factor:   5.128


  18 in total

1.  Neurosarcoidosis presenting as cerebellar mass.

Authors:  P Wiesli; K Hess; G Cathomas; C Stey
Journal:  Eur Neurol       Date:  2000       Impact factor: 1.710

2.  Tumor necrosis factor antagonist therapy and lymphoma development: twenty-six cases reported to the Food and Drug Administration.

Authors:  S Lori Brown; Mark H Greene; Sharon K Gershon; Evelyne T Edwards; M Miles Braun
Journal:  Arthritis Rheum       Date:  2002-12

Review 3.  The neurological complications of systemic sarcoidosis.

Authors:  Desmond Kidd; Huw L C Beynon
Journal:  Sarcoidosis Vasc Diffuse Lung Dis       Date:  2003-06       Impact factor: 0.670

Review 4.  Therapeutic options for sarcoidosis: new and old.

Authors:  Robert P Baughman
Journal:  Curr Opin Pulm Med       Date:  2002-09       Impact factor: 3.155

5.  Refractory neurosarcoidosis: a dramatic response to infliximab.

Authors:  John D Carter; Joanne Valeriano; Frank B Vasey; Bryan Bognar
Journal:  Am J Med       Date:  2004-08-15       Impact factor: 4.965

6.  Successful treatment of steroid-refractory neurosarcoidosis with infliximab.

Authors:  M Sollberger; F Fluri; T Baumann; S Sonnet; M Tamm; A J Steck; M Brutsche
Journal:  J Neurol       Date:  2004-06       Impact factor: 4.849

Review 7.  Neurologic manifestations in sarcoidosis: review of the literature, with a report of 23 cases.

Authors:  P Delaney
Journal:  Ann Intern Med       Date:  1977-09       Impact factor: 25.391

8.  Treatment of sarcoidosis with infliximab.

Authors:  John D Doty; Joseph E Mazur; Marc A Judson
Journal:  Chest       Date:  2005-03       Impact factor: 9.410

9.  Treatment of corticosteroid-resistant neurosarcoidosis with a short-course cyclophosphamide regimen.

Authors:  John D Doty; Joseph E Mazur; Marc A Judson
Journal:  Chest       Date:  2003-11       Impact factor: 9.410

Review 10.  Neurological complications of sarcoidosis.

Authors:  Barney J Stern
Journal:  Curr Opin Neurol       Date:  2004-06       Impact factor: 5.710

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  6 in total

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2.  Dramatic response to infliximab in refractory neurosarcoidosis.

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Journal:  Ann Indian Acad Neurol       Date:  2010-07       Impact factor: 1.383

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Review 4.  Sarcoidosis: Pitfalls and Challenging Mimickers.

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Journal:  Front Med (Lausanne)       Date:  2021-01-11

5.  Multiple sclerosis in sarcoidosis patients: Two case reports.

Authors:  Masoud Etemadifar; Armin Mehri; Nahad Sedaghat; Mehri Salari; Parsa Tavassoli Naini
Journal:  Clin Case Rep       Date:  2022-09-12

Review 6.  Off-label uses of anti-TNF therapy in three frequent disorders: Behçet's disease, sarcoidosis, and noninfectious uveitis.

Authors:  Daniel Sánchez-Cano; José Luis Callejas-Rubio; Ricardo Ruiz-Villaverde; Raquel Ríos-Fernández; Norberto Ortego-Centeno
Journal:  Mediators Inflamm       Date:  2013-08-01       Impact factor: 4.711

  6 in total

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