| Literature DB >> 17618961 |
Barbara Zahorska-Markiewicz1, Magdalena Olszanecka-Glinianowicz, Joanna Janowska, Piotr Kocełak, Elzbieta Semik-Grabarczyk, Michał Holecki, Piotr Dabrowski, Anna Skorupa.
Abstract
The aim of the present study was to determine serum concentrations of visfatin in obese women in comparison to normal-weight controls. Study subjects were 21 obese women without additional disease (age, 29.0+/-4.9 years; body mass index, 37.1+/-6.1 kg/m2) and 16 healthy, normal-weight women (age, 29.9+/-5.4 years; body mass index, 22.5+/-1.7 kg/m2). Body composition was measured by bioimpedance. Serum concentrations of visfatin were assayed with an enzyme-linked immunosorbent assay kit (Phoenix Pharmaceuticals, Burlingame, CA). Insulin was determined by radioimmunoassay and glucose by colorimetric method. Serum concentration of visfatin was significantly higher in obese women when compared to controls. Positive correlations between serum concentrations of visfatin and insulin in the obese group were found. In the control group, we observed positive correlations between serum concentrations of visfatin and glucose. In conclusion, the observed increase of visfatin in obesity may be a counterregulation preventing further glucose increase.Entities:
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Year: 2007 PMID： 17618961 DOI： 10.1016/j.metabol.2007.04.007
Source DB: PubMed Journal: Metabolism ISSN： 0026-0495 Impact factor: 8.694