BACKGROUND: Primary pulmonary mucoepidermoid carcinomas (MECs) are the third most frequent pulmonary malignant neoplasm in children, and new molecular diagnostics may prove useful in determining the biologic course of such tumors. METHODS: We analyzed the presence of a balanced t(11;19)(q21; p12~p13.11) and the MECT1-MAML2 fusion transcript in a 9-year-old girl with mucoepidermoid lung carcinoma using conventional cytogenetics, fluorescence in-situ hybridization, spectral karyotyping, high-resolution multicolor banding, and reverse transcriptase-polymerase chain reaction. RESULTS: We confirmed the t(11;19)(q21; p12~p13.11) in the tumor. Molecular analysis of the translocation breakpoint confirmed the presence of the MECT1-MAML2 fusion transcript postulated to lead to an altered cyclic adenosine monophosphate signaling in MEC. CONCLUSIONS: Our data concur with previously reported cases, in which t(11;19) appears to be the primary chromosomal aberration for pulmonary MEC in children, and that the MECT1-MAML2 fusion transcript is associated with a better prognosis in MEC tumors.
BACKGROUND:Primary pulmonary mucoepidermoid carcinomas (MECs) are the third most frequent pulmonary malignant neoplasm in children, and new molecular diagnostics may prove useful in determining the biologic course of such tumors. METHODS: We analyzed the presence of a balanced t(11;19)(q21; p12~p13.11) and the MECT1-MAML2 fusion transcript in a 9-year-old girl with mucoepidermoid lung carcinoma using conventional cytogenetics, fluorescence in-situ hybridization, spectral karyotyping, high-resolution multicolor banding, and reverse transcriptase-polymerase chain reaction. RESULTS: We confirmed the t(11;19)(q21; p12~p13.11) in the tumor. Molecular analysis of the translocation breakpoint confirmed the presence of the MECT1-MAML2 fusion transcript postulated to lead to an altered cyclic adenosine monophosphate signaling in MEC. CONCLUSIONS: Our data concur with previously reported cases, in which t(11;19) appears to be the primary chromosomal aberration for pulmonary MEC in children, and that the MECT1-MAML2 fusion transcript is associated with a better prognosis in MEC tumors.
Authors: Chunxia Cao; Ruli Gao; Min Zhang; Antonio L Amelio; Mohammad Fallahi; Zirong Chen; Yumei Gu; Chengbin Hu; Eric A Welsh; Brienne E Engel; Eric B Haura; W Douglas Cress; Lizi Wu; Maria Zajac-Kaye; Frederic J Kaye Journal: J Natl Cancer Inst Date: 2014-12-01 Impact factor: 13.506
Authors: Sergio Jaramillo; Yesenia Rojas; Bethany J Slater; Michael L Baker; M John Hicks; Jodi A Muscal; Timothy J Vece; David E Wesson; Jed G Nuchtern Journal: Pediatr Surg Int Date: 2016-01-20 Impact factor: 1.827
Authors: Melonie A Nance; Raja R Seethala; Yun Wang; Simion I Chiosea; Eugene N Myers; Jonas T Johnson; Stephen Y Lai Journal: Cancer Date: 2008-10-15 Impact factor: 6.860