| Literature DB >> 17618826 |
Wulamu Mamuti1, Yasuhito Sako, Jean-Mathieu Bart, Minoru Nakao, Xiumin Ma, Hao Wen, Akira Ito.
Abstract
Antigen B in hydatid cyst fluid of Echinococcus granulosus is a polymeric lipoprotein of 160 kDa, and is an aggregate of several different but homologous small proteins with approximately 8 kDa which are encoded by a multigene family. Four genes encoding 8-kDa-subunit monomers of the antigen B have been identified from E. granulosus. Recently, we have isolated another novel gene from Echinococcus multilocularis encoding a fifth 8-kDa-subunit of AgB (named EmAgB8/5), predominantly transcribed in the adult worm, but not in vesicles of metacestodes. In this study, we cloned and characterized two EmAgB8/5 homologue genes from E. granulosus genotypes 1 and 6 by PCR, and named as EgG1AgB8/5 and EgG6AgB8/5, respectively. The phylogenetic relationship of these genes with other genes encoding the antigen B 8-kDa-subunit monomers was also discussed.Entities:
Mesh：
Substances：
Year: 2007 PMID： 17618826 DOI： 10.1016/j.parint.2007.06.003
Source DB: PubMed Journal: Parasitol Int ISSN： 1383-5769 Impact factor: 2.230