| Literature DB >> 17618705 |
J Usuda1, T Ohira, Y Suga, T Oikawa, S Ichinose, T Inoue, K Ohtani, S Maehara, K Imai, M Kubota, Y Tsunoda, H Tsutsui, K Furukawa, T Okunaka, Y Sugimoto, H Kato.
Abstract
Development of acquired resistance to gefitinib after an initial good response is common. Recently, it was reported that this acquired resistance is related to a secondary mutation associated with a substitution of threonine by methionine at codon 790 (T790M) of the epidermal growth factor receptor (EGFR) gene. In this report, we present a "never smoking" woman with advanced lung cancer who showed acquired resistance to gefitinib, and analysis of autopsy samples revealed no evidence of EGFR mutations in either exons 18-21 or codon 790, and positive immunostaining for breast cancer resistance protein (BCRP). We describe, for the first time, a case in which expression of BCRP was associated with acquired resistance to gefitinib, independent of EGFR mutations.Entities:
Mesh：
Substances：
Year: 2007 PMID： 17618705 DOI： 10.1016/j.lungcan.2007.05.019
Source DB: PubMed Journal: Lung Cancer ISSN： 0169-5002 Impact factor: 5.705