INTRODUCTION: Total plasma homocysteine (tHcy) is an emerging risk factor for the development of atherosclerosis. However, its relationship with diabetes is still unclear. OBJECTIVES: We evaluated the association between tHcy levels and methylenetetrahydrofolate reductase (MTHFR) 677C-->T genotype in a type 2 diabetes mellitus (DM) population and their relationship with oxidized LDL (ox-LDL) according to dietary habits and vascular complications. DESIGN AND METHODS: Eighty-six DM patients were compared to 120 healthy volunteers. RESULTS: Associated higher tHcy levels and significantly higher ox-LDL levels (p<0.001) were found in DM patients compared to healthy subjects. Homozygosity for the T allele of MTHFR was more frequent in diabetics than in healthy subjects (12.8% vs. 7.2%) and it was associated with higher tHcy levels. Moreover, this elevated level was associated with significantly higher ox-LDL levels in DM patients with hypertension (p<0.05). Improving folate and vitamin C intakes could have beneficial effects on lowering the tHcy and ox-LDL levels. CONCLUSIONS: The interplay of genetic and dietary factors modulates the effect of homocysteine on cardiovascular risk factors.
INTRODUCTION: Total plasma homocysteine (tHcy) is an emerging risk factor for the development of atherosclerosis. However, its relationship with diabetes is still unclear. OBJECTIVES: We evaluated the association between tHcy levels and methylenetetrahydrofolate reductase (MTHFR) 677C-->T genotype in a type 2 diabetes mellitus (DM) population and their relationship with oxidized LDL (ox-LDL) according to dietary habits and vascular complications. DESIGN AND METHODS: Eighty-six DMpatients were compared to 120 healthy volunteers. RESULTS: Associated higher tHcy levels and significantly higher ox-LDL levels (p<0.001) were found in DMpatients compared to healthy subjects. Homozygosity for the T allele of MTHFR was more frequent in diabetics than in healthy subjects (12.8% vs. 7.2%) and it was associated with higher tHcy levels. Moreover, this elevated level was associated with significantly higher ox-LDL levels in DMpatients with hypertension (p<0.05). Improving folate and vitamin C intakes could have beneficial effects on lowering the tHcy and ox-LDL levels. CONCLUSIONS: The interplay of genetic and dietary factors modulates the effect of homocysteine on cardiovascular risk factors.
Authors: Elena C Gross; Niveditha Putananickal; Anna-Lena Orsini; Deborah R Vogt; Peter S Sandor; Jean Schoenen; Dirk Fischer Journal: Sci Rep Date: 2021-02-25 Impact factor: 4.379
Authors: N Alexandru; I Jardín; D Popov; M Simionescu; J García-Estañ; G M Salido; J A Rosado Journal: J Cell Mol Med Date: 2008-10 Impact factor: 5.310
Authors: N Alexandru; I Jardín; D Popov; M Simionescu; J García-Estañ; G M Salido; J A Rosado Journal: J Cell Mol Med Date: 2008-12 Impact factor: 5.310