Literature DB >> 17618114

Pyridinylimidazole inhibitors of Tie2 kinase.

Marcus Semones1, Yanhong Feng, Neil Johnson, Jerry L Adams, Jim Winkler, Michael Hansbury.   

Abstract

This communication details the evolution of the screening lead SB-203580, a known CSBP/p38 kinase inhibitor, into a potent and selective Tie2 tyrosine kinase inhibitor. The optimized compound 5 showed efficacy in an in vivo model of angiogenesis and a MOPC-315 plasmacytoma xenograft model.

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Year:  2007        PMID： 17618114     DOI： 10.1016/j.bmcl.2007.06.068

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  12 in total

1.  Efficacy of Tie2 receptor antagonism in angiosarcoma.

Authors:  Jason R Hasenstein; Kelsey Kasmerchak; Darya Buehler; Gholam Reza Hafez; Kevin Cleary; John S Moody; Kevin R Kozak
Journal:  Neoplasia       Date:  2012-02       Impact factor: 5.715

Review 2.  Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system.

Authors:  Hellmut G Augustin; Gou Young Koh; Gavin Thurston; Kari Alitalo
Journal:  Nat Rev Mol Cell Biol       Date:  2009-03       Impact factor: 94.444

Review 3.  Vascular anomalies: from genetics toward models for therapeutic trials.

Authors:  Melanie Uebelhoer; Laurence M Boon; Miikka Vikkula
Journal:  Cold Spring Harb Perspect Med       Date:  2012-08-01       Impact factor: 6.915

4.  Rapamycin improves TIE2-mutated venous malformation in murine model and human subjects.

Authors:  Elisa Boscolo; Nisha Limaye; Lan Huang; Kyu-Tae Kang; Julie Soblet; Melanie Uebelhoer; Antonella Mendola; Marjut Natynki; Emmanuel Seront; Sophie Dupont; Jennifer Hammer; Catherine Legrand; Carlo Brugnara; Lauri Eklund; Miikka Vikkula; Joyce Bischoff; Laurence M Boon
Journal:  J Clin Invest       Date:  2015-08-10       Impact factor: 14.808

5.  Wnt10b Gain-of-Function Improves Cardiac Repair by Arteriole Formation and Attenuation of Fibrosis.

Authors:  David T Paik; Meena Rai; Sergey Ryzhov; Lehanna N Sanders; Omonigho Aisagbonhi; Mitchell J Funke; Igor Feoktistov; Antonis K Hatzopoulos
Journal:  Circ Res       Date:  2015-09-03       Impact factor: 17.367

6.  Plasma Fibronectin Promotes Tumor Cell Survival and Invasion through Regulation of Tie2.

Authors:  Lynn M Knowles; Gunjan Malik; Jan Pilch
Journal:  J Cancer       Date:  2013-06-21       Impact factor: 4.207

7.  Tie-2 regulates the stemness and metastatic properties of prostate cancer cells.

Authors:  Kai-Dun Tang; Boris M Holzapfel; Ji Liu; Terence Kin-Wah Lee; Stephanie Ma; Lidija Jovanovic; Jiyuan An; Pamela J Russell; Judith A Clements; Dietmar W Hutmacher; Ming-Tat Ling
Journal:  Oncotarget       Date:  2016-01-19

8.  In Silico Exploration for Novel Type-I Inhibitors of Tie-2/TEK: The Performance of Different Selection Strategy in Selecting Virtual Screening Candidates.

Authors:  Peichen Pan; Huiyong Sun; Hui Liu; Dan Li; Wenfang Zhou; Xiaotian Kong; Youyong Li; Huidong Yu; Tingjun Hou
Journal:  Sci Rep       Date:  2016-11-23       Impact factor: 4.379

9.  A palladium-catalyzed synthesis of (hetero)aryl-substituted imidazoles from aryl halides, imines and carbon monoxide.

Authors:  Jevgenijs Tjutrins; Bruce A Arndtsen
Journal:  Chem Sci       Date:  2016-11-03       Impact factor: 9.825

10.  Angiopoetin-2 Signals Do Not Mediate the Hypervascularization of Islets in Type 2 Diabetes.

Authors:  Payal Shah; Navina Lueschen; Amin Ardestani; Jose Oberholzer; Johan Olerud; Per-Ola Carlsson; Kathrin Maedler
Journal:  PLoS One       Date:  2016-09-12       Impact factor: 3.240
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