| Literature DB >> 17617702 |
Hoon-Seok Yoon1, Sun-Ryung Lee, Hee-Chul Ko, Soo-Youn Choi, Ji-Gweon Park, Jeong-Kook Kim, Se-Jae Kim.
Abstract
Nobiletin contributes to pharmacological activities such as anti-cancer and anti-inflammatory effects, but little is known about its effect on melanogenesis. In this study, we found that nobiletin increased melanin content and tyrosinase activity in murine B16/F10 melanoma cells. Furthermore, inhibition of the extracellular signal-regulated kinase (ERK) pathway with U0216 resulted in inhibition of nobiletin-induced melanin synthesis and tyrosinase expression.Entities:
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Year: 2007 PMID: 17617702 DOI: 10.1271/bbb.70088
Source DB: PubMed Journal: Biosci Biotechnol Biochem ISSN: 0916-8451 Impact factor: 2.043