BACKGROUND AND AIMS: A functional promoter polymorphism in the FcRL3 gene, -169 T/C, has been shown to regulate gene expression and to play a role in several autoimmune diseases. We aimed at testing for the first time whether this gene was involved in multiple sclerosis (MS) pathogenesis. METHODS: Case-control study performed with 400 Spanish MS patients and 508 healthy subjects. Genotyping of -169 T/C and -110 G/A was ascertained by using TaqMan MGB chemistry following manufacturer suggestions (Applied Biosystems, CA, USA). RESULTS: As previously seen for other autoimmune diseases, a significant difference was observed in the distribution of -169 T/C FcRL3 genotypes between MS patients and healthy controls (p = 0.03; chi(2) = 6.99). The -169 T allele, recently associated with increased susceptibility to Addison's disease, showed a parallel effect in MS [(TT+TC) vs. CC: p = 0.013; OR = 1.55 (1.08-2.54)]. CONCLUSIONS: An increased susceptibility associated to the -169 T allele was found when MS patients and controls were compared, supporting the role of the FcRL3 locus in MS predisposition and therefore extending the evidence of its general influence on autoimmunity.
BACKGROUND AND AIMS: A functional promoter polymorphism in the FcRL3 gene, -169 T/C, has been shown to regulate gene expression and to play a role in several autoimmune diseases. We aimed at testing for the first time whether this gene was involved in multiple sclerosis (MS) pathogenesis. METHODS: Case-control study performed with 400 Spanish MSpatients and 508 healthy subjects. Genotyping of -169 T/C and -110 G/A was ascertained by using TaqMan MGB chemistry following manufacturer suggestions (Applied Biosystems, CA, USA). RESULTS: As previously seen for other autoimmune diseases, a significant difference was observed in the distribution of -169 T/CFcRL3 genotypes between MSpatients and healthy controls (p = 0.03; chi(2) = 6.99). The -169 T allele, recently associated with increased susceptibility to Addison's disease, showed a parallel effect in MS [(TT+TC) vs. CC: p = 0.013; OR = 1.55 (1.08-2.54)]. CONCLUSIONS: An increased susceptibility associated to the -169 T allele was found when MSpatients and controls were compared, supporting the role of the FcRL3 locus in MS predisposition and therefore extending the evidence of its general influence on autoimmunity.
Authors: Hao D Cheng; Henning Stöckmann; Barbara Adamczyk; Ciara A McManus; Altan Ercan; Ingrid A Holm; Pauline M Rudd; Margaret E Ackerman; Peter A Nigrovic Journal: Glycobiology Date: 2017-12-01 Impact factor: 4.313
Authors: Ju Li; Sai Ma; Linlin Shao; Chunhong Ma; Chengjiang Gao; Xiao-Hui Zhang; Ming Hou; Jun Peng Journal: Front Immunol Date: 2017-06-28 Impact factor: 7.561
Authors: Nathan Nakatsuka; Nick Patterson; Nikolaos A Patsopoulos; Nicolas Altemose; Arti Tandon; Ashley H Beecham; Jacob L McCauley; Noriko Isobe; Stephen Hauser; Philip L De Jager; David A Hafler; Jorge R Oksenberg; David Reich Journal: Sci Rep Date: 2020-10-09 Impact factor: 4.379