| Literature DB >> 17617451 |
Paul N Meyer1, Shantanu Roychowdhury, Ameet R Kini, Serhan Alkan.
Abstract
The effects of a novel heat shock protein inhibitor, 17AAG, on established APL cell lines (NB4 and R1) were analyzed. 17AAG induces apoptosis in APL cell lines both sensitive (NB4) and resistant (R1) to ATRA after 72 h of incubation. Apoptosis occurs by a mechanism different than ATRA-mediated response, as the cells do not undergo differentiation before apoptosis. Analysis of bax and bcl-2 shows that pro-apoptotic (bax) and anti-apoptotic (bcl-2) proteins are decreased in expression after incubation with 17AAG. We believe this data supports potential clinical use of agents that target HSP90 in APL patients failing conventional therapy.Entities:
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Year: 2007 PMID： 17617451 DOI： 10.1016/j.leukres.2007.05.009
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156