Literature DB >> 17616653

The role of vascular cell adhesion molecule-1 in tumor immune evasion.

T-C Wu1.   

Abstract

Tumor immune escape is a critical trait of cancer but the mechanisms involved have yet to fully emerge. One recent study has shown that tumor cells can escape T-cell immunity by overexpressing the endothelial cell adhesion molecule vascular cell adhesion molecule-1 (VCAM-1), which normally mediates leukocyte extravasion to sites of tissue inflammation. Renal cell carcinoma (RCC) was identified as one tumor type where VCAM-1 is commonly highly overexpressed. Together, our findings suggest that RCCs might exploit VCAM-1 overexpression for immune escape.

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Year:  2007        PMID： 17616653      PMCID： PMC3179385          DOI： 10.1158/0008-5472.CAN-07-1543

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  16 in total

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  36 in total

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