| Literature DB >> 17613546 |
Ahmad Miremadi1, Mikkel Z Oestergaard, Paul D P Pharoah, Carlos Caldas.
Abstract
The cancer epigenome is characterised by specific DNA methylation and chromatin modification patterns. The proteins that mediate these changes are encoded by the epigenetics genes here defined as: DNA methyltransferases (DNMT), methyl-CpG-binding domain (MBD) proteins, histone acetyltransferases (HAT), histone deacetylases (HDAC), histone methyltransferases (HMT) and histone demethylases. We review the evidence that these genes can be targeted by mutations and expression changes in human cancers.Entities:
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Year: 2007 PMID： 17613546 DOI： 10.1093/hmg/ddm021
Source DB: PubMed Journal: Hum Mol Genet ISSN： 0964-6906 Impact factor: 6.150