Literature DB >> 17613273

Gamma-glutamyltransferase, redox regulation and cancer drug resistance.

Alfonso Pompella1, Alessandro Corti, Aldo Paolicchi, Chiara Giommarelli, Franco Zunino.   

Abstract

Gamma-glutamyltransferase, a key enzyme of GSH metabolism, can modulate crucial redox-sensitive functions, such as antioxidant/antitoxic defences and cellular proliferative/apoptotic balance, with potential implications in tumour progression and drug resistance. Recent studies have elucidated the mechanisms of GGT involvement in various pathological processes suggesting its potential role as therapeutic target and diagnostic/prognostic marker.

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Year:  2007        PMID： 17613273     DOI： 10.1016/j.coph.2007.04.004

Source DB:  PubMed          Journal:  Curr Opin Pharmacol        ISSN： 1471-4892            Impact factor:   5.547


  54 in total

Review 1.  γ-Glutamyltranspeptidases: sequence, structure, biochemical properties, and biotechnological applications.

Authors:  Immacolata Castellano; Antonello Merlino
Journal:  Cell Mol Life Sci       Date:  2012-04-21       Impact factor: 9.261

2.  Model based on γ-glutamyltransferase and alkaline phosphatase for hepatocellular carcinoma prognosis.

Authors:  Xin-Sen Xu; Yong Wan; Si-Dong Song; Wei Chen; Run-Chen Miao; Yan-Yan Zhou; Ling-Qiang Zhang; Kai Qu; Si-Nan Liu; Yue-Lang Zhang; Ya-Feng Dong; Chang Liu
Journal:  World J Gastroenterol       Date:  2014-08-21       Impact factor: 5.742

3.  Chronic unpredictable stress (CUS) enhances the carcinogenic potential of 7,12-dimethylbenz(a)anthracene (DMBA) and accelerates the onset of tumor development in Swiss albino mice.

Authors:  Nida Suhail; Nayeem Bilal; Shirin Hasan; Ausaf Ahmad; Ghulam Md Ashraf; Naheed Banu
Journal:  Cell Stress Chaperones       Date:  2015-08-14       Impact factor: 3.667

4.  Gene cloning and protein expression of γ-glutamyltranspeptidases from Thermus thermophilus and Deinococcus radiodurans: comparison of molecular and structural properties with mesophilic counterparts.

Authors:  Immacolata Castellano; Anna Di Salle; Antonello Merlino; Mosè Rossi; Francesco La Cara
Journal:  Extremophiles       Date:  2011-02-05       Impact factor: 2.395

5.  Effects of GGsTop® on Collagen and Glutathione in the Oral Mucosa Using a Rat Model of 5-Fluorouracil-Induced Oral Mucositis.

Authors:  Issei Takeuchi; Riko Kawamata; Kimiko Makino
Journal:  In Vivo       Date:  2021 Jan-Feb       Impact factor: 2.155

Review 6.  Redox metabolism and malignancy.

Authors:  Christina L Grek; Kenneth D Tew
Journal:  Curr Opin Pharmacol       Date:  2010-06-04       Impact factor: 5.547

7.  Gamma-Glutamyltransferase 1 Promotes Clear Cell Renal Cell Carcinoma Initiation and Progression.

Authors:  Ankita Bansal; Danielle J Sanchez; Vivek Nimgaonkar; David Sanchez; Romain Riscal; Nicolas Skuli; M Celeste Simon
Journal:  Mol Cancer Res       Date:  2019-05-31       Impact factor: 5.852

8.  Prospective study of the association of serum gamma-glutamyltransferase with cervical intraepithelial neoplasia III and invasive cervical cancer.

Authors:  Alexander M Strasak; Georg Goebel; Hans Concin; Ruth M Pfeiffer; Larry J Brant; Gabriele Nagel; Willi Oberaigner; Nicole Concin; Günter Diem; Elfriede Ruttmann; Ulrike Gruber-Moesenbacher; Felix Offner; Alfonso Pompella; Karl P Pfeiffer; Hanno Ulmer
Journal:  Cancer Res       Date:  2010-04-13       Impact factor: 12.701

9.  Pharmacology of a mimetic of glutathione disulfide, NOV-002.

Authors:  Danyelle M Townsend; Kenneth D Tew
Journal:  Biomed Pharmacother       Date:  2008-09-17       Impact factor: 6.529

Review 10.  Radical-free biology of oxidative stress.

Authors:  Dean P Jones
Journal:  Am J Physiol Cell Physiol       Date:  2008-08-06       Impact factor: 4.249
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