Sergei G Kazarian1, Jaap van der Weerd. 1. Department of Chemical Engineering, Imperial College London, London, SW7 2AZ, UK. s.kazarian@imperial.ac.uk
Abstract
PURPOSE: Previous studies of hydroxypropyl methylcellulose (HPMC)-based tablet during exposure to water showed a number of 'fronts' moving into the tablet but led to contradictory interpretations. These fronts are related to water penetration into and dissolution of the tablet, but the exact nature can not be derived from visible photographic evidence. A method to study tablet dissolution simultaneously by Fourier transform infrared-attenuated total reflection (FTIR-ATR) imaging and macro-photography can assist in providing correct interpretation of the observed fronts. METHODS: Therefore, the combination of macro-photography and FTIR-ATR spectroscopic imaging was developed and used to interpret the physical changes leading to the observed fronts. Buflomedyl pyridoxal phosphate (BPP), a coloured drug, was used as a model drug. RESULTS: The quantitative results obtained by FTIR-ATR imaging enabled the attribution of the three observed fronts (inside to outside) to: (1) true water penetration, possibly combined with (partial) dissolution of buflomedyl pyridoxal phosphate (BPP); (2) total gellification of HPMC; (3) erosion front. CONCLUSIONS: The method to study dissolution of a tablet simultaneously by FTIR-ATR imaging and macro-photography has been developed and used to obtain reliable interpretation of the fronts observed during tablet dissolution.
PURPOSE: Previous studies of hydroxypropyl methylcellulose (HPMC)-based tablet during exposure to water showed a number of 'fronts' moving into the tablet but led to contradictory interpretations. These fronts are related to water penetration into and dissolution of the tablet, but the exact nature can not be derived from visible photographic evidence. A method to study tablet dissolution simultaneously by Fourier transform infrared-attenuated total reflection (FTIR-ATR) imaging and macro-photography can assist in providing correct interpretation of the observed fronts. METHODS: Therefore, the combination of macro-photography and FTIR-ATR spectroscopic imaging was developed and used to interpret the physical changes leading to the observed fronts. Buflomedyl pyridoxal phosphate (BPP), a coloured drug, was used as a model drug. RESULTS: The quantitative results obtained by FTIR-ATR imaging enabled the attribution of the three observed fronts (inside to outside) to: (1) true water penetration, possibly combined with (partial) dissolution of buflomedyl pyridoxal phosphate (BPP); (2) total gellification of HPMC; (3) erosion front. CONCLUSIONS: The method to study dissolution of a tablet simultaneously by FTIR-ATR imaging and macro-photography has been developed and used to obtain reliable interpretation of the fronts observed during tablet dissolution.
Authors: Przemyslaw P Dorozyński; Piotr Kulinowski; Aleksander Mendyk; Anna Młynarczyk; Renata Jachowicz Journal: AAPS PharmSciTech Date: 2010-03-30 Impact factor: 3.246
Authors: Piotr Kulinowski; Anna Młynarczyk; Przemysław Dorożyński; Krzysztof Jasiński; Marco L H Gruwel; Bogusław Tomanek; Władysław P Węglarz Journal: Pharm Res Date: 2012-08-25 Impact factor: 4.200
Authors: Samy Yassin; Daniel J Goodwin; Andrew Anderson; Juraj Sibik; D Ian Wilson; Lynn F Gladden; J Axel Zeitler Journal: J Pharm Sci Date: 2015-06-12 Impact factor: 3.534
Authors: Kateřina Punčochová; Andrew V Ewing; Michaela Gajdošová; Tomáš Pekárek; Josef Beránek; Sergei G Kazarian; František Štěpánek Journal: Pharm Res Date: 2016-08-29 Impact factor: 4.200
Authors: Runqiao Dong; James C DiNunzio; Brian P Regler; Walter Wasylaschuk; Adam Socia; J Axel Zeitler Journal: Pharmaceutics Date: 2021-06-23 Impact factor: 6.321