Literature DB >> 1761197

The interaction of peripherally and centrally administered dexamethasone and RU 38486 on morphine analgesia in mice.

S Pieretti1, A Capasso, A Di Giannuario, A Loizzo, L Sorrentino.   

Abstract

1. Dexamethasone or RU 38486 were administered intraperitoneally or intracerebroventricularly to mice 10 or 120 min before morphine administration. The interaction of these drugs with the analgesic effects of morphine was examined using the hot plate test. 2. Dexamethasone i.p. pretreatment reduced analgesic responses to morphine injected 120 min but not 10 min after dexamethasone; i.c.v. injection of dexamethasone 10 and 120 min before morphine administration was effective in reducing morphine analgesia. 3. RU 38486 i.c.v. pretreatment (but not i.p. pretreatment) performed 120 (but not 10) min before morphine administration enhanced morphine analgesic effects. 4. These results, particularly the effects of drug interaction for i.c.v. administration, strongly confirm a central site for dexamethasone and RU 38486 action.

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Year:  1991        PMID： 1761197     DOI： 10.1016/0306-3623(91)90232-u

Source DB:  PubMed          Journal:  Gen Pharmacol        ISSN： 0306-3623


  4 in total

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2.  Dexamethasone-induced selective inhibition of the central mu opioid receptor: functional in vivo and in vitro evidence in rodents.

Authors:  S Pieretti; A Di Giannuario; M R Domenici; S Sagratella; A Capasso; L Sorrentino; A Loizzo
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4.  P-glycoprotein modulates morphine uptake into the CNS: a role for the non-steroidal anti-inflammatory drug diclofenac.

Authors:  Lucy Sanchez-Covarrubias; Lauren M Slosky; Brandon J Thompson; Yifeng Zhang; Mei-Li Laracuente; Kristin M DeMarco; Patrick T Ronaldson; Thomas P Davis
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  4 in total

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