Literature DB >> 17611943

Conformationally restrained aromatic analogues of fosmidomycin and FR900098.

Thomas Kurz1, Katrin Schlüter, Miriam Pein, Christoph Behrendt, Bärbel Bergmann, Rolf D Walter.   

Abstract

The synthesis and in-vitro antimalarial activity of conformationally restrained bis(pivaloyloxymethyl) ester analogues of the natural product fosmidomycin is presented. In contrast to alpha-aryl-substituted analogues, conformationally restrained aromatic analogues exhibit only moderate in-vitro antimalarial activity against the chloroquine-sensitive strain 3D7 of Plasmodium falciparum. The most active derivative displays an IC(50) value of 47 microM.

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Year:  2007        PMID： 17611943     DOI： 10.1002/ardp.200700013

Source DB:  PubMed          Journal:  Arch Pharm (Weinheim)        ISSN： 0365-6233            Impact factor:   3.751


  7 in total

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Review 3.  Biochemistry of the non-mevalonate isoprenoid pathway.

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4.  Antimalarial and Structural Studies of Pyridine-containing Inhibitors of 1-Deoxyxylulose-5-phosphate Reductoisomerase.

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Journal:  ACS Med Chem Lett       Date:  2013-02-14       Impact factor: 4.345

5.  Antibacterial and antitubercular activity of fosmidomycin, FR900098, and their lipophilic analogs.

Authors:  Eugene Uh; Emily R Jackson; Géraldine San Jose; Marcus Maddox; Robin E Lee; Richard E Lee; Helena I Boshoff; Cynthia S Dowd
Journal:  Bioorg Med Chem Lett       Date:  2011-10-05       Impact factor: 2.823

6.  Design of Potential Bisubstrate Inhibitors against Mycobacterium tuberculosis (Mtb) 1-Deoxy-D-Xylulose 5-Phosphate Reductoisomerase (Dxr)-Evidence of a Novel Binding Mode.

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Journal:  Medchemcomm       Date:  2013-07-01       Impact factor: 3.597

7.  Potent, specific MEPicides for treatment of zoonotic staphylococci.

Authors:  Rachel L Edwards; Isabel Heueck; Soon Goo Lee; Ishaan T Shah; Justin J Miller; Andrew J Jezewski; Marwa O Mikati; Xu Wang; Robert C Brothers; Kenneth M Heidel; Damon M Osbourn; Carey-Ann D Burnham; Sophie Alvarez; Stephanie A Fritz; Cynthia S Dowd; Joseph M Jez; Audrey R Odom John
Journal:  PLoS Pathog       Date:  2020-06-04       Impact factor: 6.823
  7 in total

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