Literature DB >> 17611773

Fetal calf serum inhibits virus genome expression in Madin-Darby canine kidney cells persistently infected with influenza A virus.

Md Jaber Hossain1, Isamu Mori, Li Dong, Beixing Liu, Yoshinobu Kimura.   

Abstract

A cell line of Madin-Darby canine kidney (MDCK) cells persistently infected with human influenza A virus has been established and designated as MDCK-IVpi cells. Production of progeny virus in MDCK-IVpi cells was suppressed when the cells were incubated in the presence of 10% fetal calf serum (FCS). FCS impaired virus mRNA synthesis in MDCK-IVpi cells, which resulted in a scarcity of virus proteins for virion formation. However, MDCK-IVpi cells well supported the growth of superinfecting heterologous influenza viruses, even in the presence of FCS. A certain fetuin-like substance in FCS might be responsible for the observed inhibition of virus replication.

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Year:  2007        PMID: 17611773     DOI: 10.1007/s00430-007-0054-1

Source DB:  PubMed          Journal:  Med Microbiol Immunol        ISSN: 0300-8584            Impact factor:   3.402


  38 in total

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Journal:  J Gen Virol       Date:  1994-07       Impact factor: 3.891

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Journal:  J Virol       Date:  1980-12       Impact factor: 5.103

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  1 in total

1.  Characterization of the Role of Extracellular Vesicles Released from Chicken Tracheal Cells in the Antiviral Responses against Avian Influenza Virus.

Authors:  Kelsey O'Dowd; Laura Sánchez; Jennifer Ben Salem; Francis Beaudry; Neda Barjesteh
Journal:  Membranes (Basel)       Date:  2021-12-31
  1 in total

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