| Literature DB >> 17611001 |
Brijesh Kumar Srivastava1, Mukul R Jain, Manish Solanki, Rina Soni, Darshan Valani, Sunil Gupta, Bhupendra Mishra, Vijay Takale, Prashant Kapadnis, Harilal Patel, Purvi Pandya, Jayendra Z Patel, Pankaj R Patel.
Abstract
Design and synthesis of novel piperazinylaryloxazolidinones possessing heteroaryl groups are described and their in vitro antibacterial activities have been evaluated by MIC assay. Compounds (S)-N-[3-{3-fluoro-4-[4-[3-(5-nitrofuran-2-yl)-acryloyl]-piperazin-1-yl]-phenyl}-2-oxo-oxazolidin-5-yl-methyl] acetamide (6o), (S)-N-[3-{3-fluoro-4-[4-[3-(5-nitrothien-2-yl)-acryloyl]-piperazin-1-yl]-phenyl}-2-oxo-oxazolidin-5-yl-methyl] acetamide (6p) and N-oxide of (S)-N-[3-{3-fluoro-4-[4-[3-(5-nitrofuran-2-yl)-acryloyl]-piperazin-1-yl]-phenyl}-2-oxo-oxazolidin-5-yl-methyl] acetamide (9) showed superior antibacterial activities than linezolid and also active against the linezolid resistant Staphylococcus aureus strains.Entities:
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Year: 2007 PMID： 17611001 DOI： 10.1016/j.ejmech.2007.05.003
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514