| Literature DB >> 17610813 |
David Sulzer1, Yvonne Schmitz.
Abstract
Pacemaking activity in adult substantia nigra (SN) dopamine neurons relies on L-type Ca2+ channels, but a surprising study in Nature by Chan et al. demonstrates that blockade of these channels by dihydropyridines re-establishes the pacemaking driven by sodium and HCN channels found in juvenile SN. This shift protects SN neurons in chemical models of Parkinson's disease (PD), suggesting that elevated intracellular Ca2+ participates in SN cell loss and that dihydropyridines may provide therapy in PD.Entities:
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Year: 2007 PMID： 17610813 DOI： 10.1016/j.neuron.2007.06.023
Source DB: PubMed Journal: Neuron ISSN： 0896-6273 Impact factor: 17.173