OBJECTIVE: To assess outcomes in patients with lupus nephritis treated with immunosuppressives compared to those treated with cyclophosphamide in a cohort study and in a matched cohort study. METHODS: Patients with active renal disease treated with immunosuppressive/cytotoxic medications were selected from the University of Toronto Lupus Clinic database. Five outcomes were evaluated: all-cause mortality, renal failure, reversal of active renal disease, relapse of active renal disease, and toxicity. RESULTS: There were no differences in the outcomes of death, renal failure, reversal or relapse of active renal disease, or toxicity in those using or not using cyclophosphamide. CONCLUSION: Antimetabolites should be considered standard of care for patients with lupus nephritis both for induction and for maintenance therapy.
OBJECTIVE: To assess outcomes in patients with lupus nephritis treated with immunosuppressives compared to those treated with cyclophosphamide in a cohort study and in a matched cohort study. METHODS:Patients with active renal disease treated with immunosuppressive/cytotoxic medications were selected from the University of Toronto Lupus Clinic database. Five outcomes were evaluated: all-cause mortality, renal failure, reversal of active renal disease, relapse of active renal disease, and toxicity. RESULTS: There were no differences in the outcomes of death, renal failure, reversal or relapse of active renal disease, or toxicity in those using or not using cyclophosphamide. CONCLUSION: Antimetabolites should be considered standard of care for patients with lupus nephritis both for induction and for maintenance therapy.
Authors: Xana Kim-Howard; Amit K Maiti; Juan-Manuel Anaya; Gail R Bruner; Elizabeth Brown; Joan T Merrill; Jeffrey C Edberg; Michelle A Petri; John D Reveille; Rosalind Ramsey-Goldman; Graciela S Alarcon; Timothy J Vyse; Gary Gilkeson; Robert P Kimberly; Judith A James; Joel M Guthridge; John B Harley; Swapan K Nath Journal: Ann Rheum Dis Date: 2009-11-25 Impact factor: 19.103
Authors: George K Bertsias; Maria Tektonidou; Zahir Amoura; Martin Aringer; Ingeborg Bajema; Jo H M Berden; John Boletis; Ricard Cervera; Thomas Dörner; Andrea Doria; Franco Ferrario; Jürgen Floege; Frederic A Houssiau; John P A Ioannidis; David A Isenberg; Cees G M Kallenberg; Liz Lightstone; Stephen D Marks; Alberto Martini; Gabriela Moroni; Irmgard Neumann; Manuel Praga; Matthias Schneider; Argyre Starra; Vladimir Tesar; Carlos Vasconcelos; Ronald F van Vollenhoven; Helena Zakharova; Marion Haubitz; Caroline Gordon; David Jayne; Dimitrios T Boumpas Journal: Ann Rheum Dis Date: 2012-07-31 Impact factor: 19.103