Literature DB >> 17610004

Partial HELLP syndrome in pregnancy complicated by recurrent deep vein thromboses and palmar skin lesions in a patient with prothrombin gene 20210a mutation and antiphospholipid antibodies: an unusual case.

Ronald A Asherson1, Cathy Spargo, Jose A Gómez-Puerta.   

Abstract

A patient who developed thrombocytopenia and hypertension accompanied by high levels of antiphospholipid antibodies and abnormal liver function tests in the absence of a hemolytic anemia necessitating termination of pregnancy developed bilateral lower limb thromboses accompanied by painful maculo papular lesions on the palms of both hands a few days after ending the pregnancy. She was then also found to have a prothrombin gene G20210A mutation. She was treated with anticoagulation therapy, but her postpartum course was further complicated by pulmonary embolus. A Greenfield filter was inserted into the inferior vena cava. On low molecular weight heparin, her next pregnancy was uneventful and without any complications.

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Year:  2007        PMID: 17610004     DOI: 10.1007/s10067-007-0683-1

Source DB:  PubMed          Journal:  Clin Rheumatol        ISSN: 0770-3198            Impact factor:   2.980


  21 in total

1.  Skin nodules and macules resembling vasculitis in the antiphospholipid syndrome--a report of two cases.

Authors:  R A Asherson; S Jacobelli; H Rosenberg; P Mckee; G R Hughes
Journal:  Clin Exp Dermatol       Date:  1992-07       Impact factor: 3.470

Review 2.  Catastrophic antiphospholipid syndrome during pregnancy and puerperium: maternal and fetal characteristics of 15 cases.

Authors:  José A Gómez-Puerta; Ricard Cervera; Gerard Espinosa; Ronald A Asherson; Mario García-Carrasco; Izaias P da Costa; Danieli C O Andrade; Eduardo F Borba; Alexander Makatsaria; Silvia Bucciarelli; Manuel Ramos-Casals; Josep Font
Journal:  Ann Rheum Dis       Date:  2007-01-12       Impact factor: 19.103

3.  The HELLP syndrome at 16 weeks gestation: possible association with the antiphospholipid syndrome.

Authors:  L P McMahon; J Smith
Journal:  Aust N Z J Obstet Gynaecol       Date:  1997-08       Impact factor: 2.100

4.  Inherited thrombophilia and first venous thromboembolism during pregnancy and puerperium.

Authors:  Ida Martinelli; Valerio De Stefano; Emanuela Taioli; Katia Paciaroni; Elena Rossi; Pier Mannuccio Mannucci
Journal:  Thromb Haemost       Date:  2002-05       Impact factor: 5.249

Review 5.  Catastrophic antiphospholipid (Asherson's) syndrome and genetic thrombophilic disorders in obstetrics.

Authors:  A Makatsariya; R A Asherson; V Bitsadze; S Baimuradova; S Akinshina
Journal:  Autoimmun Rev       Date:  2006-07-24       Impact factor: 9.754

6.  Single and combined prothrombotic factors in patients with idiopathic venous thromboembolism: prevalence and risk assessment.

Authors:  O Salomon; D M Steinberg; A Zivelin; S Gitel; R Dardik; N Rosenberg; S Berliner; A Inbal; A Many; A Lubetsky; D Varon; U Martinowitz; U Seligsohn
Journal:  Arterioscler Thromb Vasc Biol       Date:  1999-03       Impact factor: 8.311

Review 7.  [Antiphospholipid syndrome and venous thromboembolism: the role of congenital thrombophilia].

Authors:  Daniela Poli; Gian Franco Gensini
Journal:  Ann Ital Med Int       Date:  2005 Oct-Dec

8.  An association between refractory HELLP syndrome and antiphospholipid antibodies during pregnancy; a report of 2 cases.

Authors:  M H Ornstein; J H Rand
Journal:  J Rheumatol       Date:  1994-07       Impact factor: 4.666

9.  Hepatic infarctions during pregnancy are associated with the antiphospholipid syndrome and in addition with complete or incomplete HELLP syndrome.

Authors:  R Pauzner; M Dulitzky; H Carp; H Mayan; R Kenett; Z Farfel; A Many
Journal:  J Thromb Haemost       Date:  2003-08       Impact factor: 5.824

10.  Acute renal failure complicating HELLP syndrome, SLE and anti-phospholipid syndrome: successful outcome using plasma exchange therapy.

Authors:  G Roberts; M M Gordon; D Porter; A G Jardine; I W Gibson
Journal:  Lupus       Date:  2003       Impact factor: 2.911

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  2 in total

1.  Timing of cholecystectomy after acute severe pancreatitis in pregnancy.

Authors:  Mousa Talebi-Bakhshayesh; Alireza Mohammadzadeh; Ali Zargar
Journal:  Malays J Med Sci       Date:  2015 May-Jun

2.  The HELLP syndrome, antiphospholipid antibodies, and syndromes.

Authors:  Ronald A Asherson; Claudio Galarza-Maldonado; Jose Sanin-Blair
Journal:  Clin Rheumatol       Date:  2007-10-03       Impact factor: 2.980

  2 in total

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