| Literature DB >> 17609851 |
Hae-Yun Jung1, Jae Sook Sung1, Young Mi Whang1, Hyoung Doo Shin2, Byung Lae Park2, Jun Suk Kim1, Sang Won Shin1, Hee Yun Seo1, Hwa Jung Sung1, In Keun Choi1, Sang Cheul Oh1, Jae Hong Seo1, Yeul Hong Kim3.
Abstract
The fragile histidine triad (FHIT), which was located on chromosome 3p14.2, was currently considered a promising candidate for a tumor suppressor gene. FHIT performed a crucial function in the tumorigenesis of lung cancer. The inactivation of FHIT via genetic alterations, including the chromosomal deletions and aberrant transcription, are often associated with lung cancer. In this study, the association between FHIT and lung cancer development was evaluated in a study of Korean patients. A total of 299 Korean lung cancer patients and 296 control subjects were recruited into this study. Direct DNA sequencing and TaqMan analysis were employed. Logistic regression analyses were conducted in order to characterize the association between FHIT polymorphisms and lung cancer risk. Via direct sequencing in 24 Korean individuals, 27 sequence variants were identified. Eleven of these polymorphisms were selected for a larger scale genotyping (n = 595). Our finding indicated that the polymorphisms and haplotypes in the FHIT gene are not associated with lung cancer in the Korean population.Entities:
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Year: 2007 PMID： 17609851 DOI： 10.1007/s10038-007-0169-7
Source DB: PubMed Journal: J Hum Genet ISSN： 1434-5161 Impact factor: 3.172