Literature DB >> 17609206

The tetraspan protein EMP2 regulates expression of caveolin-1.

Ashley Forbes1, Madhuri Wadehra, Sergei Mareninov, Shawn Morales, Kaori Shimazaki, Lynn K Gordon, Jonathan Braun.   

Abstract

Caveolin-1 is the primary component of caveolae and functions in a variety of intracellular activities, including membrane trafficking and signal transduction. EMP2 (epithelial membrane protein 2) is a tetraspan protein recently identified as a novel regulator of caveolin-1 expression. In this study, we analyzed the mechanism of EMP2-mediated caveolin-1 regulation. In NIH 3T3 cells and in the human retinal pigment epithelium cell line (ARPE-19), EMP2 regulates caveolin-1 transcription and more substantially its protein levels. EMP2-mediated down-regulation of caveolin-1 does not affect caveolin-1 translational efficiency, phosphorylation, or proteasome-mediated degradation. Analysis of caveolin-1 protein half-life indicates the EMP2-mediated loss of caveolin-1 occurs rapidly. Protease inhibition and laser confocal microscopy associates this fate with specific intracellular compartmentalization, including early lysosomal delivery. These findings elucidate a new mechanism of caveolin-1 regulation and define an additional role for EMP2 as a key regulator of cell membrane composition.

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Year:  2007        PMID： 17609206     DOI： 10.1074/jbc.M702117200

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  24 in total

1.  Anti-EMP2 diabody blocks epithelial membrane protein 2 (EMP2) and FAK mediated collagen gel contraction in ARPE-19 cells.

Authors:  Shawn A Morales; David G Telander; Sergey Mareninov; Agnes Nagy; Madhuri Wadehra; Jonathan Braun; Lynn K Gordon
Journal:  Exp Eye Res       Date:  2012-06-19       Impact factor: 3.467

2.  A highly conserved motif at the COOH terminus dictates endoplasmic reticulum exit and cell surface expression of NKCC2.

Authors:  Nancy Zaarour; Sylvie Demaretz; Nadia Defontaine; David Mordasini; Kamel Laghmani
Journal:  J Biol Chem       Date:  2009-06-17       Impact factor: 5.157

3.  Epithelial membrane protein 2 controls VEGF expression in ARPE-19 cells.

Authors:  Shawn A Morales; David G Telander; Deanna Leon; Krisztina Forward; Jonathan Braun; Madhuri Wadehra; Lynn K Gordon
Journal:  Invest Ophthalmol Vis Sci       Date:  2013-03-28       Impact factor: 4.799

Review 4.  Caveolins and caveolae in ocular physiology and pathophysiology.

Authors:  Xiaowu Gu; Alaina M Reagan; Mark E McClellan; Michael H Elliott
Journal:  Prog Retin Eye Res       Date:  2016-09-21       Impact factor: 21.198

5.  Epithelial membrane protein 2 governs transepithelial migration of neutrophils into the airspace.

Authors:  Wan-Chi Lin; Kymberly M Gowdy; Jennifer H Madenspacher; Rachel L Zemans; Kazuko Yamamoto; Miranda Lyons-Cohen; Hideki Nakano; Kyathanahalli Janardhan; Carmen J Williams; Donald N Cook; Joseph P Mizgerd; Michael B Fessler
Journal:  J Clin Invest       Date:  2020-01-02       Impact factor: 14.808

6.  Interaction Between Peroxisome Proliferator Activated Receptor δ and Epithelial Membrane Protein 2 Polymorphisms Influences HDL-C Levels in the Chinese Population.

Authors:  Tingjing Ke; Rajkumar Dorajoo; Yi Han; Chiea-Chuen Khor; Rob M van Dam; Jian-Min Yuan; Woon-Puay Koh; Jianjun Liu; Yik Ying Teo; Daniel Y T Goh; E Shyong Tai; Tien Yin Wong; Ching-Yu Cheng; Yechiel Friedlander; Chew-Kiat Heng
Journal:  Ann Hum Genet       Date:  2016-09       Impact factor: 1.670

7.  Mutations in EMP2 cause childhood-onset nephrotic syndrome.

Authors:  Heon Yung Gee; Shazia Ashraf; Xiaoyang Wan; Virginia Vega-Warner; Julian Esteve-Rudd; Svjetlana Lovric; Humphrey Fang; Toby W Hurd; Carolin E Sadowski; Susan J Allen; Edgar A Otto; Emine Korkmaz; Joseph Washburn; Shawn Levy; David S Williams; Sevcan A Bakkaloglu; Anna Zolotnitskaya; Fatih Ozaltin; Weibin Zhou; Friedhelm Hildebrandt
Journal:  Am J Hum Genet       Date:  2014-05-08       Impact factor: 11.025

8.  Flotillin-1 stabilizes caveolin-1 in intestinal epithelial cells.

Authors:  Elena V Vassilieva; Andrei I Ivanov; Asma Nusrat
Journal:  Biochem Biophys Res Commun       Date:  2008-12-31       Impact factor: 3.575

9.  Loss of Epithelial Membrane Protein 2 Aggravates Podocyte Injury via Upregulation of Caveolin-1.

Authors:  Xiaoyang Wan; Zhaohong Chen; Won-Il Choi; Heon Yung Gee; Friedhelm Hildebrandt; Weibin Zhou
Journal:  J Am Soc Nephrol       Date:  2015-08-11       Impact factor: 10.121

10.  Clinical and genetic heterogeneity in familial steroid-sensitive nephrotic syndrome.

Authors:  Guillaume Dorval; Olivier Gribouval; Vanesa Martinez-Barquero; Eduardo Machuca; Marie-Josèphe Tête; Véronique Baudouin; Stéphane Benoit; Imen Chabchoub; Gérard Champion; Dominique Chauveau; Hassib Chehade; Chokri Chouchane; Sylvie Cloarec; Pierre Cochat; Karin Dahan; Jacques Dantal; Yahsou Delmas; Georges Deschênes; Phillippe Dolhem; Dominique Durand; Zelal Ekinci; Khalil El Karoui; Michel Fischbach; Jean-Pierre Grunfeld; Vincent Guigonis; Mongia Hachicha; Julien Hogan; Maryvonne Hourmant; Aurélie Hummel; Nassim Kamar; Thierry Krummel; Didier Lacombe; Brigitte Llanas; Laurent Mesnard; Nabil Mohsin; Patrick Niaudet; Hubert Nivet; Paloma Parvex; Christine Pietrement; Loic de Pontual; Claire Pouteil Noble; David Ribes; Pierre Ronco; Eric Rondeau; Marion Sallee; Michel Tsimaratos; Tim Ulinski; Rémi Salomon; Corinne Antignac; Olivia Boyer
Journal:  Pediatr Nephrol       Date:  2017-10-23       Impact factor: 3.714
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