OBJECTIVES: To preliminarily examine the association between cardiac output, a measure of systemic blood flow, and structural brain magnetic resonance imaging indices of white matter hyperintensities (WMHs). DESIGN: Cross-sectional. SETTING: University medical setting. PARTICIPANTS: Thirty-six older adults without dementia with prevalent cardiovascular disease (aged 56-85). MEASUREMENTS: Cardiac output, WMHs. RESULTS: Partial correlations, adjusting for age and history of hypertension, yielded an inverse relationship between WMHs adjacent to subcortical nuclei and cardiac output (correlation coefficient=-0.48, P=.03); as cardiac output decreased, WMHs increased significantly. No significant associations were found between cardiac output and total WMHs or periventricular WMHs. CONCLUSION: These preliminary data suggest that systemic blood flow, measured according to cardiac output, is inversely associated with WMHs adjacent to the subcortical nuclei. Cerebrovascular degeneration and the chronicity of hypoperfusion may exacerbate the susceptibility of white matter integrity to alterations in blood flow in older adults.
OBJECTIVES: To preliminarily examine the association between cardiac output, a measure of systemic blood flow, and structural brain magnetic resonance imaging indices of white matter hyperintensities (WMHs). DESIGN: Cross-sectional. SETTING: University medical setting. PARTICIPANTS: Thirty-six older adults without dementia with prevalent cardiovascular disease (aged 56-85). MEASUREMENTS: Cardiac output, WMHs. RESULTS: Partial correlations, adjusting for age and history of hypertension, yielded an inverse relationship between WMHs adjacent to subcortical nuclei and cardiac output (correlation coefficient=-0.48, P=.03); as cardiac output decreased, WMHs increased significantly. No significant associations were found between cardiac output and total WMHs or periventricular WMHs. CONCLUSION: These preliminary data suggest that systemic blood flow, measured according to cardiac output, is inversely associated with WMHs adjacent to the subcortical nuclei. Cerebrovascular degeneration and the chronicity of hypoperfusion may exacerbate the susceptibility of white matter integrity to alterations in blood flow in older adults.
Authors: F-E de Leeuw; J C de Groot; M Oudkerk; J C M Witteman; A Hofman; J van Gijn; M M B Breteler Journal: Brain Date: 2002-04 Impact factor: 13.501
Authors: Lauren E Salminen; Peter R Schofield; Kerrie D Pierce; Yi Zhao; Xi Luo; Youdan Wang; David H Laidlaw; Ryan P Cabeen; Thomas E Conturo; David F Tate; Erbil Akbudak; Elizabeth M Lane; Jodi M Heaps; Jacob D Bolzenius; Laurie M Baker; Lee M Cagle; Robert H Paul Journal: Behav Brain Res Date: 2015-08-28 Impact factor: 3.332
Authors: Ronald A Cohen; Athena Poppas; Daniel E Forman; Karin F Hoth; Andreana P Haley; John Gunstad; Angela L Jefferson; David F Tate; Robert H Paul; Lawrence H Sweet; Mokato Ono; Beth A Jerskey; Marie Gerhard-Herman Journal: J Clin Exp Neuropsychol Date: 2008-06-16 Impact factor: 2.475
Authors: Angela L Jefferson; Christopher M Holland; David F Tate; Istvan Csapo; Athena Poppas; Ronald A Cohen; Charles R G Guttmann Journal: Neurobiol Aging Date: 2009-03-09 Impact factor: 4.673
Authors: Lauren E Salminen; Peter R Schofield; Kerrie D Pierce; Thomas E Conturo; David F Tate; Elizabeth M Lane; Jodi M Heaps; Jacob D Bolzenius; Laurie M Baker; Erbil Akbudak; Robert H Paul Journal: Age (Dordr) Date: 2014-07-01
Authors: Angela L Jefferson; Jayandra J Himali; Alexa S Beiser; Rhoda Au; Joseph M Massaro; Sudha Seshadri; Philimon Gona; Carol J Salton; Charles DeCarli; Christopher J O'Donnell; Emelia J Benjamin; Philip A Wolf; Warren J Manning Journal: Circulation Date: 2010-08-02 Impact factor: 29.690
Authors: Bhaswati Roy; Mary A Woo; Danny J J Wang; Gregg C Fonarow; Ronald M Harper; Rajesh Kumar Journal: Eur J Heart Fail Date: 2017-05-30 Impact factor: 15.534
Authors: Farzin Irani; Lawrence H Sweet; Andreana P Haley; John J Gunstad; Beth A Jerskey; Richard C Mulligan; Angela L Jefferson; Athena Poppas; Ronald A Cohen Journal: Brain Imaging Behav Date: 2009-12 Impact factor: 3.978
Authors: Michael L Alosco; Adam M Brickman; Mary Beth Spitznagel; Erica Y Griffith; Atul Narkhede; Naftali Raz; Ronald Cohen; Lawrence H Sweet; Lisa H Colbert; Richard Josephson; Joel Hughes; Jim Rosneck; John Gunstad Journal: J Neurol Sci Date: 2013-03-23 Impact factor: 3.181