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Literature DB >> 17606906

Src phosphorylation of cortactin enhances actin assembly.

Shandiz Tehrani¹, Nenad Tomasevic, Scott Weed, Roman Sakowicz, John A Cooper.

Abstract

Src kinase mediates growth factor signaling and causes oncogenic transformation, which includes dramatic changes in the actin cytoskeleton, cell shape, and motility. Cortactin was discovered as a substrate for Src. How phosphorylation of cortactin can enhance actin assembly is unknown. Here, using an actin assembly system reconstituted from purified components, we demonstrate for the first time a biochemical mechanism by which Src phosphorylation of cortactin affects actin assembly. The adaptor Nck is an important component of the system, linking phosphorylated cortactin with neuronal WASp (N-WASp) and WASp-interacting protein (WIP) to activate Arp2/3 complex.

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Year: 2007 PMID： 17606906 PMCID： PMC1924558 DOI： 10.1073/pnas.0701077104

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

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