BACKGROUND: A month-of-birth (MOB) effect has been shown in multiple sclerosis (MS). METHODS: Our chi(2) analyses looked at whether this MOB effect differed by MS phenotype ("bout onset," "primary progressive"). RESULTS: The MOB effect was derived from "bout onset" MS patients (May/November ratio = 1.43; chi(2) = 17.32, df = 1, p = 0.000032). CONCLUSIONS: An unspecified environmental effect in early development can influence both multiple sclerosis susceptibility and phenotype.
BACKGROUND: A month-of-birth (MOB) effect has been shown in multiple sclerosis (MS). METHODS: Our chi(2) analyses looked at whether this MOB effect differed by MS phenotype ("bout onset," "primary progressive"). RESULTS: The MOB effect was derived from "bout onset" MS patients (May/November ratio = 1.43; chi(2) = 17.32, df = 1, p = 0.000032). CONCLUSIONS: An unspecified environmental effect in early development can influence both multiple sclerosis susceptibility and phenotype.
Authors: Tzu-Yun McDowell; Sania Amr; Patricia Langenberg; Walter Royal; Christopher Bever; William J Culpepper; Douglas D Bradham Journal: Neuroepidemiology Date: 2010-03-18 Impact factor: 3.282
Authors: S V Ramagopalan; I M Yee; D A Dyment; S-M Orton; R A Marrie; A D Sadovnick; G C Ebers Journal: Neurology Date: 2009-06-10 Impact factor: 9.910
Authors: Giulio Disanto; George Chaplin; Julia M Morahan; Gavin Giovannoni; Elina Hyppönen; George C Ebers; Sreeram V Ramagopalan Journal: BMC Med Date: 2012-07-06 Impact factor: 8.775