Literature DB >> 17606687

Determination of the primary target of a quinolone drug and the effect of quinolone resistance-conferring mutations by measuring quinolone sensitivity based on its mode of action.

Emily S Pfeiffer1, Hiroshi Hiasa.   

Abstract

We used an assay to measure quinolone sensitivity as a shift in the position of the cleavage-religation equilibrium. This assay was found to be useful in identifying the primary target of a quinolone drug and assessing the effect of quinolone resistance-conferring mutations.

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Year:  2007        PMID： 17606687      PMCID： PMC2043222          DOI： 10.1128/AAC.00362-07

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  15 in total

Review 1.  Tumor cell death induced by topoisomerase-targeting drugs.

Authors:  T K Li; L F Liu
Journal:  Annu Rev Pharmacol Toxicol       Date:  2001       Impact factor: 13.820

Review 2.  DNA topoisomerases: structure, function, and mechanism.

Authors:  J J Champoux
Journal:  Annu Rev Biochem       Date:  2001       Impact factor: 23.643

Review 3.  Cellular roles of DNA topoisomerases: a molecular perspective.

Authors:  James C Wang
Journal:  Nat Rev Mol Cell Biol       Date:  2002-06       Impact factor: 94.444

4.  Targeting of DNA gyrase in Streptococcus pneumoniae by sparfloxacin: selective targeting of gyrase or topoisomerase IV by quinolones.

Authors:  X S Pan; L M Fisher
Journal:  Antimicrob Agents Chemother       Date:  1997-02       Impact factor: 5.191

5.  Escherichia coli mutants thermosensitive for deoxyribonucleic acid gyrase subunit A: effects on deoxyribonucleic acid replication, transcription, and bacteriophage growth.

Authors:  K N Kreuzer; N R Cozzarelli
Journal:  J Bacteriol       Date:  1979-11       Impact factor: 3.490

Review 6.  Fluoroquinolones: action and resistance.

Authors:  Karl Drlica; Muhammad Malik
Journal:  Curr Top Med Chem       Date:  2003       Impact factor: 3.295

7.  The Glu-84 of the ParC subunit plays critical roles in both topoisomerase IV-quinolone and topoisomerase IV-DNA interactions.

Authors:  Hiroshi Hiasa
Journal:  Biochemistry       Date:  2002-10-01       Impact factor: 3.162

8.  Staphylococcus aureus gyrase-quinolone-DNA ternary complexes fail to arrest replication fork progression in vitro. Effects of salt on the DNA binding mode and the catalytic activity of S. aureus gyrase.

Authors:  Hiroshi Hiasa; Molly E Shea; Christine M Richardson; Michael N Gwynn
Journal:  J Biol Chem       Date:  2002-12-23       Impact factor: 5.157

9.  Merbarone inhibits the catalytic activity of human topoisomerase IIalpha by blocking DNA cleavage.

Authors:  J M Fortune; N Osheroff
Journal:  J Biol Chem       Date:  1998-07-10       Impact factor: 5.157

10.  The mechanism of inhibition of topoisomerase IV by quinolone antibacterials.

Authors:  A B Khodursky; N R Cozzarelli
Journal:  J Biol Chem       Date:  1998-10-16       Impact factor: 5.157
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  5 in total

1.  Fluoroquinolones stimulate the DNA cleavage activity of topoisomerase IV by promoting the binding of Mg(2+) to the second metal binding site.

Authors:  Lisa M Oppegard; Heidi A Schwanz; Tyrell R Towle; Robert J Kerns; Hiroshi Hiasa
Journal:  Biochim Biophys Acta       Date:  2015-12-23

2.  Novel acridine-based compounds that exhibit an anti-pancreatic cancer activity are catalytic inhibitors of human topoisomerase II.

Authors:  Lisa M Oppegard; Andrei V Ougolkov; Doris N Luchini; Renee A Schoon; John R Goodell; Harneet Kaur; Daniel D Billadeau; David M Ferguson; Hiroshi Hiasa
Journal:  Eur J Pharmacol       Date:  2008-12-03       Impact factor: 4.432

3.  Two forms of ribosomal protein L2 of Escherichia coli that inhibit DnaA in DNA replication.

Authors:  Sundari Chodavarapu; Magdalena M Felczak; Jon M Kaguni
Journal:  Nucleic Acids Res       Date:  2011-02-02       Impact factor: 16.971

4.  Role of the water-metal ion bridge in mediating interactions between quinolones and Escherichia coli topoisomerase IV.

Authors:  Katie J Aldred; Erin J Breland; Vladislava Vlčková; Marie-Paule Strub; Keir C Neuman; Robert J Kerns; Neil Osheroff
Journal:  Biochemistry       Date:  2014-08-21       Impact factor: 3.162

Review 5.  Mechanism of quinolone action and resistance.

Authors:  Katie J Aldred; Robert J Kerns; Neil Osheroff
Journal:  Biochemistry       Date:  2014-03-07       Impact factor: 3.162
  5 in total

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