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Literature DB >> 17606640

Control of C. elegans hermaphrodite gonad size and shape by vab-3/Pax6-mediated regulation of integrin receptors.

Christopher M Meighan¹, Jean E Schwarzbauer.

Abstract

Integrin receptors for extracellular matrix are critical for cell motility, but the signals that determine when to stop are not known. Analysis of distal tip cell (DTC) migration during gonadogenesis in Caenorhabditis elegans has revealed the importance of transcription factor vab-3/Pax6 in regulating the alpha integrin genes, ina-1 and pat-2. Utilizing vab-3 mutants, we show that the down-regulation of ina-1 is necessary for DTC migration cessation and the up-regulation of pat-2 is required for directionality. These results demonstrate concomitant, but distinct roles in migration for each integrin. Notably, transcriptional control of migration termination provides a new mechanism for regulation of morphogenesis and organ size.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2007 PMID： 17606640 PMCID： PMC1899471 DOI： 10.1101/gad.1534807

Source DB: PubMed Journal: Genes Dev ISSN： 0890-9369 Impact factor: 11.361

28 in total

1. Roles for beta(pat-3) integrins in development and function of Caenorhabditis elegans muscles and gonads.

Authors: M Lee; E J Cram; B Shen; J E Schwarzbauer
Journal: J Biol Chem Date: 2001-07-25 Impact factor: 5.157

2. Rapid gene mapping in Caenorhabditis elegans using a high density polymorphism map.

Authors: S R Wicks; R T Yeh; W R Gish; R H Waterston; R H Plasterk
Journal: Nat Genet Date: 2001-06 Impact factor: 38.330

3. PCR fusion-based approach to create reporter gene constructs for expression analysis in transgenic C. elegans.

Authors: Oliver Hobert
Journal: Biotechniques Date: 2002-04 Impact factor: 1.993

4. A monomeric red fluorescent protein.

Authors: Robert E Campbell; Oded Tour; Amy E Palmer; Paul A Steinbach; Geoffrey S Baird; David A Zacharias; Roger Y Tsien
Journal: Proc Natl Acad Sci U S A Date: 2002-06-11 Impact factor: 11.205

Review 5. Integrins: bidirectional, allosteric signaling machines.

Authors: Richard O Hynes
Journal: Cell Date: 2002-09-20 Impact factor: 41.582

Review 6. The Caenorhabditis elegans gonad: a test tube for cell and developmental biology.

Authors: E J Hubbard; D Greenstein
Journal: Dev Dyn Date: 2000-05 Impact factor: 3.780

7. The Caenorhabditis elegans Six/sine oculis class homeobox gene ceh-32 is required for head morphogenesis.

Authors: C Dozier; H Kagoshima; G Niklaus; G Cassata; T R Bürglin
Journal: Dev Biol Date: 2001-08-15 Impact factor: 3.582

Review 8. Functional consequences of integrin gene mutations in mice.

Authors: D Bouvard; C Brakebusch; E Gustafsson; A Aszódi; T Bengtsson; A Berna; R Fässler
Journal: Circ Res Date: 2001-08-03 Impact factor: 17.367

9. A conserved interaction between beta1 integrin/PAT-3 and Nck-interacting kinase/MIG-15 that mediates commissural axon navigation in C. elegans.

Authors: Patrice Poinat; Adèle De Arcangelis; Satis Sookhareea; Xiaoping Zhu; Edward M Hedgecock; Michel Labouesse; Elisabeth Georges-Labouesse
Journal: Curr Biol Date: 2002-04-16 Impact factor: 10.834

9. RACK-1 acts with Rac GTPase signaling and UNC-115/abLIM in Caenorhabditis elegans axon pathfinding and cell migration.

Authors: Rafael S Demarco; Erik A Lundquist
Journal: PLoS Genet Date: 2010-11-18 Impact factor: 5.917

10. Molecular signatures of cell migration in C. elegans Q neuroblasts.

Authors: Guangshuo Ou; Ronald D Vale
Journal: J Cell Biol Date: 2009-04-06 Impact factor: 10.539

Control of C. elegans hermaphrodite gonad size and shape by vab-3/Pax6-mediated regulation of integrin receptors.

1. Roles for beta(pat-3) integrins in development and function of Caenorhabditis elegans muscles and gonads.

2. Rapid gene mapping in Caenorhabditis elegans using a high density polymorphism map.

3. PCR fusion-based approach to create reporter gene constructs for expression analysis in transgenic C. elegans.

4. A monomeric red fluorescent protein.

Review 5. Integrins: bidirectional, allosteric signaling machines.

Review 6. The Caenorhabditis elegans gonad: a test tube for cell and developmental biology.

7. The Caenorhabditis elegans Six/sine oculis class homeobox gene ceh-32 is required for head morphogenesis.

Review 8. Functional consequences of integrin gene mutations in mice.

9. A conserved interaction between beta1 integrin/PAT-3 and Nck-interacting kinase/MIG-15 that mediates commissural axon navigation in C. elegans.

10. A systematic RNA interference screen reveals a cell migration gene network in C. elegans.

1. CCDC-55 is required for larval development and distal tip cell migration in Caenorhabditis elegans.

2. The integrin adhesion complex changes its composition and function during morphogenesis of an epithelium.

Review 3. Extracellular matrix in development: insights from mechanisms conserved between invertebrates and vertebrates.

Review 4. Nucleoside diphosphate kinases (NDPKs) in animal development.

Review 5. Regulating distal tip cell migration in space and time.

6. mig-38, a novel gene that regulates distal tip cell turning during gonadogenesis in C. elegans hermaphrodites.

7. Transcriptionally regulated cell adhesion network dictates distal tip cell directionality.

Review 8. Basement Membranes in the Worm: A Dynamic Scaffolding that Instructs Cellular Behaviors and Shapes Tissues.

9. RACK-1 acts with Rac GTPase signaling and UNC-115/abLIM in Caenorhabditis elegans axon pathfinding and cell migration.

10. Molecular signatures of cell migration in C. elegans Q neuroblasts.