Expanding donor options: marginal, living, and split donors.

One of the most important factors in the increasing number of liver transplantations performed in the United States is the growing acceptance of marginal grafts, which are defined as organs at increased risk for poor function or failure that may subject the recipient to greater risks of morbidity or mortality. Based on encouraging results, a growing number of liver transplantation centers are broadening their criteria for transplantation of marginal grafts. This article discusses the use of the extended criteria donor liver, split-liver, and living-donor liver transplantation.