Rapidly expanding brain mass.

Amebic encephalitis is an uncommon central nervous system infection, usually caused by Acanthamoeba spp., which generally occurs in immunocompromised individuals. The infection might start from a minor, slowly progressive, skin ulceration that can be present for weeks to months before neurologic changes occur. We present a 40-year-old male with multiple visceral allografts, on immunosuppression, 9 months after transplantation. He had an active skin rash previously diagnosed as graft-versus-host disease by biopsy. The condition of the patient declined rapidly.