OBJECTIVE: To investigate relations between EEG measures and performance on tests of global cognition, memory, language and executive functioning. METHODS: Twenty-two controls, 18 patients with mild cognitive impairment (MCI) and 16 with probable Alzheimer's disease (AD) underwent neuropsychological and EEG investigations. We used the following EEG measures: theta relative power during eyes closed, alpha reactivity during memory activation (i.e. the percentual decrease in alpha power as compared to eyes closed) and alpha coherence during eyes closed and memory activation. RESULTS: Theta relative power was increased in AD patients as compared with controls (p<0.001) and MCI patients (p<0.01) and related to decreased performance in all cognitive domains. Alpha reactivity was decreased in AD patients as compared with controls (p<0.005) and related to decreased performance on tests of global cognition, memory and executive functioning. Alpha coherence did not differ between groups and was unrelated to cognition. CONCLUSIONS: EEG power measures were associated with decreased performance on tests of global cognition, memory, language and executive functioning, while coherence measures were not. SIGNIFICANCE: The EEG yielded several power measures related to cognitive functions. These EEG power measures might prove useful in prospective studies aimed at predicting longitudinal cognitive decline and dementia.
OBJECTIVE: To investigate relations between EEG measures and performance on tests of global cognition, memory, language and executive functioning. METHODS: Twenty-two controls, 18 patients with mild cognitive impairment (MCI) and 16 with probable Alzheimer's disease (AD) underwent neuropsychological and EEG investigations. We used the following EEG measures: theta relative power during eyes closed, alpha reactivity during memory activation (i.e. the percentual decrease in alpha power as compared to eyes closed) and alpha coherence during eyes closed and memory activation. RESULTS: Theta relative power was increased in ADpatients as compared with controls (p<0.001) and MCI patients (p<0.01) and related to decreased performance in all cognitive domains. Alpha reactivity was decreased in ADpatients as compared with controls (p<0.005) and related to decreased performance on tests of global cognition, memory and executive functioning. Alpha coherence did not differ between groups and was unrelated to cognition. CONCLUSIONS: EEG power measures were associated with decreased performance on tests of global cognition, memory, language and executive functioning, while coherence measures were not. SIGNIFICANCE: The EEG yielded several power measures related to cognitive functions. These EEG power measures might prove useful in prospective studies aimed at predicting longitudinal cognitive decline and dementia.
Authors: Claudio Babiloni; Claudio Del Percio; Marina Boccardi; Roberta Lizio; Susanna Lopez; Filippo Carducci; Nicola Marzano; Andrea Soricelli; Raffaele Ferri; Antonio Ivano Triggiani; Annapaola Prestia; Serenella Salinari; Paul E Rasser; Erol Basar; Francesco Famà; Flavio Nobili; Görsev Yener; Derya Durusu Emek-Savaş; Loreto Gesualdo; Ciro Mundi; Paul M Thompson; Paolo M Rossini; Giovanni B Frisoni Journal: Neurobiol Aging Date: 2014-09-21 Impact factor: 4.673
Authors: Markus Waser; Heinrich Garn; Reinhold Schmidt; Thomas Benke; Peter Dal-Bianco; Gerhard Ransmayr; Helena Schmidt; Stephan Seiler; Günter Sanin; Florian Mayer; Georg Caravias; Dieter Grossegger; Wolfgang Frühwirt; Manfred Deistler Journal: J Neural Transm (Vienna) Date: 2015-09-28 Impact factor: 3.575
Authors: M E López; P Cuesta; P Garcés; P N Castellanos; S Aurtenetxe; R Bajo; A Marcos; M L Delgado; P Montejo; J L López-Pantoja; F Maestú; A Fernandez Journal: Age (Dordr) Date: 2014-02-16
Authors: Christopher S Y Benwell; Paula Davila-Pérez; Peter J Fried; Richard N Jones; Thomas G Travison; Emiliano Santarnecchi; Alvaro Pascual-Leone; Mouhsin M Shafi Journal: Neurobiol Aging Date: 2019-10-14 Impact factor: 4.673