| Literature DB >> 17604374 |
Vanessa Müller1, Juliana H Chávez, Flávio H Reginatto, Silvana M Zucolotto, Rivaldo Niero, Dionezine Navarro, Rosendo A Yunes, Eloir P Schenkel, Célia R M Barardi, Carlos R Zanetti, Cláudia M O Simões.
Abstract
This paper describes the screening of different South American plant extracts and fractions. Aqueous and organic extracts were prepared and tested for antiherpetic (HSV-1, KOS and 29R strains) and antirabies (PV strain) activities. The evaluation of the potential antiviral activity of these extracts was performed by using an MTT assay for HSV-1, and by a viral cytopathic effect (CPE) inhibitory method for rabies virus (RV). The results were expressed as 50% cytotoxicity (CC(50)) for MTT assay and 50% effective (EC(50)) concentrations for CPE, and with them it was possible to calculate the selectivity indices (SI = CC(50)/EC(50)) of each tested material. From the 18 extracts/fractions tested, six extracts and four fractions showed antiviral action. Ilex paraguariensis, Lafoensia pacari, Passiflora edulis, Rubus imperialis and Slonea guianensis showed values of SI > 7 against HSV-1 KOS and 29-R strains and Alamanda schottii showed a SI of 5.6 against RV, PV strain.Entities:
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Year: 2007 PMID： 17604374 DOI： 10.1002/ptr.2198
Source DB: PubMed Journal: Phytother Res ISSN： 0951-418X Impact factor: 5.878