BACKGROUND: Although opioid receptor function in humans is clearly reduced during opioid dependence, what happens to the receptor in early abstinence is not understood. AIMS: This study sought to examine changes in opioid receptor availability in early abstinence from opioid dependence. METHOD: Ten people with opioid dependence who had completed in-patient detoxification and 20 healthy controls underwent [11C]-diprenorphine positron emission tomography. Clinical variables were assessed with structured questionnaires. Opioid receptor binding was characterised as the volume of distribution of [11C]-diprenorphine using a template of predefined brain volumes and an exploratory voxel-by-voxel analysis. RESULTS: Compared with controls, participants with opioid dependence had increased [11C]-diprenorphine binding in the whole brain and in 15 of the 21 a priori regions studied. CONCLUSIONS: This study suggests that opioid receptor binding is increased throughout the brain in early abstinence from dependent opioid use. These data complement the findings in cocaine and alcohol dependence.
BACKGROUND: Although opioid receptor function in humans is clearly reduced during opioid dependence, what happens to the receptor in early abstinence is not understood. AIMS: This study sought to examine changes in opioid receptor availability in early abstinence from opioid dependence. METHOD: Ten people with opioid dependence who had completed in-patient detoxification and 20 healthy controls underwent [11C]-diprenorphine positron emission tomography. Clinical variables were assessed with structured questionnaires. Opioid receptor binding was characterised as the volume of distribution of [11C]-diprenorphine using a template of predefined brain volumes and an exploratory voxel-by-voxel analysis. RESULTS: Compared with controls, participants with opioid dependence had increased [11C]-diprenorphine binding in the whole brain and in 15 of the 21 a priori regions studied. CONCLUSIONS: This study suggests that opioid receptor binding is increased throughout the brain in early abstinence from dependent opioid use. These data complement the findings in cocaine and alcohol dependence.
Authors: H K Karlsson; J J Tuulari; L Tuominen; J Hirvonen; H Honka; R Parkkola; S Helin; P Salminen; P Nuutila; L Nummenmaa Journal: Mol Psychiatry Date: 2015-10-13 Impact factor: 15.992
Authors: Jarkko Johansson; Jussi Hirvonen; Zsófia Lovró; Laura Ekblad; Valtteri Kaasinen; Olli Rajasilta; Semi Helin; Jouni Tuisku; Saija Sirén; Mirka Pennanen; Arvind Agrawal; Roger Crystal; Petri J Vainio; Hannu Alho; Mika Scheinin Journal: Neuropsychopharmacology Date: 2019-03-13 Impact factor: 7.853
Authors: Inge Mick; Anna C Ramos; Jim Myers; Paul R Stokes; Samantha Chandrasekera; David Erritzoe; Maria A Mendez; Roger N Gunn; Eugenii A Rabiner; Graham E Searle; José C F Galduróz; Adam D Waldman; Henrietta Bowden-Jones; Luke Clark; David J Nutt; Anne R Lingford-Hughes Journal: Addict Biol Date: 2016-10-13 Impact factor: 4.280
Authors: G Savulich; R Riccelli; L Passamonti; M Correia; J F W Deakin; R Elliott; R S A Flechais; A R Lingford-Hughes; J McGonigle; A Murphy; D J Nutt; C Orban; L M Paterson; L J Reed; D G Smith; J Suckling; R Tait; E M Taylor; B J Sahakian; T W Robbins; K D Ersche Journal: Transl Psychiatry Date: 2017-03-07 Impact factor: 6.222
Authors: Inge Mick; Jim Myers; Anna C Ramos; Paul R A Stokes; David Erritzoe; Alessandro Colasanti; Roger N Gunn; Eugenii A Rabiner; Graham E Searle; Adam D Waldman; Mark C Parkin; Alan D Brailsford; José C F Galduróz; Henrietta Bowden-Jones; Luke Clark; David J Nutt; Anne R Lingford-Hughes Journal: Neuropsychopharmacology Date: 2015-11-10 Impact factor: 7.853