| Literature DB >> 17601735 |
Huifang Wu1, Trudy A Smith, Hongyan Huang, Jia Bei Wang, Jeffrey R Deschamps, Andrew Coop.
Abstract
The orvinols are a class of potent opioids which have been extensively studied, yet little is known about the effects of introducing substituents into the 18- and 19-positions. The etheno bridge of thevinone was hydroxylated to give both the 18- and 19-hydroxyl substituted thevinols. After 3-O-demethylation to the corresponding orvinols, binding and GTPgammaS functional assays indicated that hydroxyl substitution at the 18- and 19-positions differentially affects the mu opioid efficacy of orvinols.Entities:
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Year: 2007 PMID： 17601735 PMCID： PMC2084076 DOI： 10.1016/j.bmcl.2007.06.050
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823