Literature DB >> 17601578

Identification of trehalose dimycolate (cord factor) in Mycobacterium leprae.

Masanori Kai1, Yukiko Fujita, Yumi Maeda, Noboru Nakata, Shinzo Izumi, Ikuya Yano, Masahiko Makino.   

Abstract

Glycolipids of Mycobacterium leprae obtained from armadillo tissue nodules infected with the bacteria were analyzed. Mass spectrometric analysis of the glycolipids indicated the presence of trehalose 6,6'-dimycolate (TDM) together with trehalose 6-monomycolate (TMM) and phenolic glycolipid-I (PGL-I). The analysis showed that M. leprae-derived TDM and TMM possessed both alpha- and keto-mycolates centering at C78 in the former and at C81 or 83 in the latter subclasses, respectively. For the first time, MALDI-TOF mass analyses showed the presence of TDM in M. leprae.

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Year:  2007        PMID： 17601578     DOI： 10.1016/j.febslet.2007.06.029

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  7 in total

1.  Differentiation of Langerhans Cells from Monocytes and Their Specific Function in Inducing IL-22-Specific Th Cells.

Authors:  Yohei Otsuka; Eri Watanabe; Eiji Shinya; Sadayuki Okura; Hidehisa Saeki; Teunis B H Geijtenbeek; Hidemi Takahashi
Journal:  J Immunol       Date:  2018-10-15       Impact factor: 5.422

2.  Exposure to a cutinase-like serine esterase triggers rapid lysis of multiple mycobacterial species.

Authors:  Yong Yang; Alexandra Bhatti; Danxia Ke; Mercedes Gonzalez-Juarrero; Anne Lenaerts; Laurent Kremer; Yann Guerardel; Peijun Zhang; Anil K Ojha
Journal:  J Biol Chem       Date:  2012-11-15       Impact factor: 5.157

3.  The Mycobacterium tuberculosis virulence factor trehalose dimycolate imparts desiccation resistance to model mycobacterial membranes.

Authors:  Christopher W Harland; David Rabuka; Carolyn R Bertozzi; Raghuveer Parthasarathy
Journal:  Biophys J       Date:  2008-03-07       Impact factor: 4.033

4.  Diagnosis of tuberculosis: the experience at a specialized diagnostic laboratory.

Authors:  Anita Mashta; Pooja Mishra; Sonia Philipose; S Tamilzhalagan; Hanif Mahmud; Sangeeta Bhaskar; Pramod Upadhyay
Journal:  J Negat Results Biomed       Date:  2011-11-18

5.  Secretory phosphatases deficient mutant of Mycobacterium tuberculosis imparts protection at the primary site of infection in guinea pigs.

Authors:  Priyanka Chauhan; P Vineel Reddy; Ramandeep Singh; Neetika Jaisinghani; Sheetal Gandotra; Anil K Tyagi
Journal:  PLoS One       Date:  2013-10-18       Impact factor: 3.240

6.  Profiling of Intracellular Metabolites: An Approach to Understanding the Characteristic Physiology of Mycobacterium leprae.

Authors:  Yuji Miyamoto; Tetsu Mukai; Masanori Matsuoka; Masanori Kai; Yumi Maeda; Masahiko Makino
Journal:  PLoS Negl Trop Dis       Date:  2016-08-01

7.  Induction of tumor-specific CD8+ cytotoxic T lymphocytes from naïve human T cells by using Mycobacterium-derived mycolic acid and lipoarabinomannan-stimulated dendritic cells.

Authors:  Yuji Tomita; Eri Watanabe; Masumi Shimizu; Yasuyuki Negishi; Yukihiro Kondo; Hidemi Takahashi
Journal:  Cancer Immunol Immunother       Date:  2019-09-17       Impact factor: 6.968
  7 in total

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