Ravinder D Reddy1, Matcheri S Keshavan, Jeffrey K Yao. 1. Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pittsburgh, PA 15213, USA.
Abstract
OBJECTIVES: To determine whether blunted serotonergic responsivity, indicated by decreased platelet dense granule secretion (DGS), occurs in neuroleptic-naïve patients with schizophrenia, as observed previously in chronic schizophrenia. DESIGN AND METHODS: Serotonin (5-HT)-amplified DGS was examined in 40 first-episode neuroleptic-naïve patients (24 with schizophrenia and 16 with mood disorders) and 24 healthy subjects. RESULTS: Healthy controls showed robustly increased DGS. Schizophrenic patients showed very modest DGS increases; mood disorder patients showed intermediate response. CONCLUSIONS: Blunted DGS appears to a characteristic of schizophrenia that is observed in the treatment-naïve condition.
OBJECTIVES: To determine whether blunted serotonergic responsivity, indicated by decreased platelet dense granule secretion (DGS), occurs in neuroleptic-naïve patients with schizophrenia, as observed previously in chronic schizophrenia. DESIGN AND METHODS: Serotonin (5-HT)-amplified DGS was examined in 40 first-episode neuroleptic-naïve patients (24 with schizophrenia and 16 with mood disorders) and 24 healthy subjects. RESULTS: Healthy controls showed robustly increased DGS. Schizophrenicpatients showed very modest DGS increases; mood disorderpatients showed intermediate response. CONCLUSIONS: Blunted DGS appears to a characteristic of schizophrenia that is observed in the treatment-naïve condition.
Authors: Jeffrey K Yao; Sharon Magan; Ali F Sonel; John A Gurklis; Richard Sanders; Ravinder D Reddy Journal: Prostaglandins Leukot Essent Fatty Acids Date: 2004-09 Impact factor: 4.006