| Literature DB >> 17600706 |
Hideo Kitagawa1, Tomohiro Ozawa, Sho Takahata, Maiko Iida.
Abstract
Novel FabK inhibitors with antibacterial activity against Streptococcus pneumoniae were synthesized and evaluated. Through SAR studies of our initial hit compound 2-(1H-benz[d]imidazol-2-ylthio)-N-(6-methoxycarbonylbenzo[d]thiazol-2-yl)acetamide, a series of novel phenylimidazole derivatives were discovered as potent FabK inhibitors.Entities:
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Year: 2007 PMID： 17600706 DOI： 10.1016/j.bmcl.2007.06.040
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823