OBJECTIVE: STK15 is a serine threonine kinase which assists chromosomal separation and mitotic spindle stability through interaction with the centrosome during mitosis. We hypothesized that STK15 polymorphisms might modulate the risk of uterine cancer. METHODS: We used a hospital-based case-control study to assess the association between STK15 polymorphisms and risk of uterine cancer. Cases and controls were matched on age, race, and smoking status. Two common STK15 single nucleotide polymorphisms (SNPs), F31I (T/A), and V57I (G/A), were genotyped. Odds ratios (OR) and 95% confidence intervals (CI) were obtained using unconditional logistic regression analysis. RESULTS: A total of 193 women with uterine cancer and 218 controls were genotyped for both SNPs. After adjustment for age, race, and smoking status for the F31I SNP, the homozygous variant genotype (AA) was associated with a significantly increased uterine cancer risk (OR 10.2; 95% CI 2.23-46.5). Individuals with the heterozygous genotype (TA) and a history of tobacco use also exhibited an increased risk for uterine cancer (OR 2.63; 95% CI 1.20-5.76). For the V57I SNP, neither the homozygous (AA) nor the heterozygous (GA) variant genotypes were associated with significantly altered risk for uterine cancer (OR 0.76; 95% CI 0.18-3.25 and OR 0.88; 95% CI 0.52-1.49). CONCLUSION: Our study demonstrates that STK15 F31I SNP is associated with an increased risk for uterine cancer. Confirmation of this pilot study is needed in a larger case-control population to evaluate this genetic variant with other known risk factors for uterine cancer.
OBJECTIVE:STK15 is a serine threonine kinase which assists chromosomal separation and mitotic spindle stability through interaction with the centrosome during mitosis. We hypothesized that STK15 polymorphisms might modulate the risk of uterine cancer. METHODS: We used a hospital-based case-control study to assess the association between STK15 polymorphisms and risk of uterine cancer. Cases and controls were matched on age, race, and smoking status. Two common STK15 single nucleotide polymorphisms (SNPs), F31I (T/A), and V57I (G/A), were genotyped. Odds ratios (OR) and 95% confidence intervals (CI) were obtained using unconditional logistic regression analysis. RESULTS: A total of 193 women with uterine cancer and 218 controls were genotyped for both SNPs. After adjustment for age, race, and smoking status for the F31I SNP, the homozygous variant genotype (AA) was associated with a significantly increased uterine cancer risk (OR 10.2; 95% CI 2.23-46.5). Individuals with the heterozygous genotype (TA) and a history of tobacco use also exhibited an increased risk for uterine cancer (OR 2.63; 95% CI 1.20-5.76). For the V57I SNP, neither the homozygous (AA) nor the heterozygous (GA) variant genotypes were associated with significantly altered risk for uterine cancer (OR 0.76; 95% CI 0.18-3.25 and OR 0.88; 95% CI 0.52-1.49). CONCLUSION: Our study demonstrates that STK15F31I SNP is associated with an increased risk for uterine cancer. Confirmation of this pilot study is needed in a larger case-control population to evaluate this genetic variant with other known risk factors for uterine cancer.
Authors: Sujatha Venkataraman; Irina Alimova; Tiffany Tello; Peter S Harris; Jeffrey A Knipstein; Andrew M Donson; Nicholas K Foreman; Arthur K Liu; Rajeev Vibhakar Journal: J Neurooncol Date: 2012-01-15 Impact factor: 4.130
Authors: Kristen N Stevens; Xianshu Wang; Zachary Fredericksen; V Shane Pankratz; James Cerhan; Celine M Vachon; Janet E Olson; Fergus J Couch Journal: Breast Cancer Res Treat Date: 2011-05-24 Impact factor: 4.872
Authors: Kristen S Purrington; Seth Slettedahl; Manjeet K Bolla; Kyriaki Michailidou; Kamila Czene; Heli Nevanlinna; Stig E Bojesen; Irene L Andrulis; Angela Cox; Per Hall; Jane Carpenter; Drakoulis Yannoukakos; Christopher A Haiman; Peter A Fasching; Arto Mannermaa; Robert Winqvist; Hermann Brenner; Annika Lindblom; Georgia Chenevix-Trench; Javier Benitez; Anthony Swerdlow; Vessela Kristensen; Pascal Guénel; Alfons Meindl; Hatef Darabi; Mikael Eriksson; Rainer Fagerholm; Kristiina Aittomäki; Carl Blomqvist; Børge G Nordestgaard; Sune F Nielsen; Henrik Flyger; Xianshu Wang; Curtis Olswold; Janet E Olson; Anna Marie Mulligan; Julia A Knight; Sandrine Tchatchou; Malcolm W R Reed; Simon S Cross; Jianjun Liu; Jingmei Li; Keith Humphreys; Christine Clarke; Rodney Scott; Florentia Fostira; George Fountzilas; Irene Konstantopoulou; Brian E Henderson; Fredrick Schumacher; Loic Le Marchand; Arif B Ekici; Arndt Hartmann; Matthias W Beckmann; Jaana M Hartikainen; Veli-Matti Kosma; Vesa Kataja; Arja Jukkola-Vuorinen; Katri Pylkäs; Saila Kauppila; Aida Karina Dieffenbach; Christa Stegmaier; Volker Arndt; Sara Margolin; Rosemary Balleine; Jose Ignacio Arias Perez; M Pilar Zamora; Primitiva Menéndez; Alan Ashworth; Michael Jones; Nick Orr; Patrick Arveux; Pierre Kerbrat; Thérèse Truong; Peter Bugert; Amanda E Toland; Christine B Ambrosone; France Labrèche; Mark S Goldberg; Martine Dumont; Argyrios Ziogas; Eunjung Lee; Gillian S Dite; Carmel Apicella; Melissa C Southey; Jirong Long; Martha Shrubsole; Sandra Deming-Halverson; Filomena Ficarazzi; Monica Barile; Paolo Peterlongo; Katarzyna Durda; Katarzyna Jaworska-Bieniek; Robert A E M Tollenaar; Caroline Seynaeve; Thomas Brüning; Yon-Dschun Ko; Carolien H M Van Deurzen; John W M Martens; Mieke Kriege; Jonine D Figueroa; Stephen J Chanock; Jolanta Lissowska; Ian Tomlinson; Michael J Kerin; Nicola Miller; Andreas Schneeweiss; William J Tapper; Susan M Gerty; Lorraine Durcan; Catriona Mclean; Roger L Milne; Laura Baglietto; Isabel dos Santos Silva; Olivia Fletcher; Nichola Johnson; Laura J Van'T Veer; Sten Cornelissen; Asta Försti; Diana Torres; Thomas Rüdiger; Anja Rudolph; Dieter Flesch-Janys; Stefan Nickels; Caroline Weltens; Giuseppe Floris; Matthieu Moisse; Joe Dennis; Qin Wang; Alison M Dunning; Mitul Shah; Judith Brown; Jacques Simard; Hoda Anton-Culver; Susan L Neuhausen; John L Hopper; Natalia Bogdanova; Thilo Dörk; Wei Zheng; Paolo Radice; Anna Jakubowska; Jan Lubinski; Peter Devillee; Hiltrud Brauch; Maartje Hooning; Montserrat García-Closas; Elinor Sawyer; Barbara Burwinkel; Frederick Marmee; Diana M Eccles; Graham G Giles; Julian Peto; Marjanka Schmidt; Annegien Broeks; Ute Hamann; Jenny Chang-Claude; Diether Lambrechts; Paul D P Pharoah; Douglas Easton; V Shane Pankratz; Susan Slager; Celine M Vachon; Fergus J Couch Journal: Hum Mol Genet Date: 2014-06-13 Impact factor: 6.150