Literature DB >> 1759906

Interleukin-2 enhances production in 24 hours of infectious human immunodeficiency virus type 1 in vitro by naturally infected mononuclear cells from seropositive donors.

B Todd1, J H Pope, P Georghiou.   

Abstract

When peripheral blood mononuclear cells from HIV-1 seropositive patients were treated with rIL-2 in vitro a rapid increase of 2-12 fold in production of extracellular infectious HIV-1 occurred, in 6 of 9 experiments. Overall, the increase in the 9 experiments was significant (p less than 0.01) and provides more direct evidence for an enhancing role of IL-2 in naturally infected cells.

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Year:  1991        PMID： 1759906     DOI： 10.1007/bf01316757

Source DB:  PubMed          Journal:  Arch Virol        ISSN： 0304-8608            Impact factor:   2.574


  14 in total

1.  Recovery of AIDS-associated retroviruses from patients with AIDS or AIDS-related conditions and from clinically healthy individuals.

Authors:  J A Levy; J Shimabukuro
Journal:  J Infect Dis       Date:  1985-10       Impact factor: 5.226

2.  IL-2 addiction: withdrawal of growth factor activates a suicide program in dependent T cells.

Authors:  R C Duke; J J Cohen
Journal:  Lymphokine Res       Date:  1986

3.  The value of MLA 144 culture fluid for the isolation of human immunodeficiency virus.

Authors:  J H Pope; F Bisshop; B McRandle; J Blok; C W Schmidt; R J Kemp
Journal:  Immunol Cell Biol       Date:  1989-04       Impact factor: 5.126

4.  The reservoir for HIV-1 in human peripheral blood is a T cell that maintains expression of CD4.

Authors:  S M Schnittman; M C Psallidopoulos; H C Lane; L Thompson; M Baseler; F Massari; C H Fox; N P Salzman; A S Fauci
Journal:  Science       Date:  1989-07-21       Impact factor: 47.728

5.  T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV.

Authors:  D Klatzmann; E Champagne; S Chamaret; J Gruest; D Guetard; T Hercend; J C Gluckman; L Montagnier
Journal:  Nature       Date:  1984 Dec 20-1985 Jan 2       Impact factor: 49.962

6.  The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus.

Authors:  A G Dalgleish; P C Beverley; P R Clapham; D H Crawford; M F Greaves; R A Weiss
Journal:  Nature       Date:  1984 Dec 20-1985 Jan 2       Impact factor: 49.962

7.  Isolation of human T-cell leukemia virus in acquired immune deficiency syndrome (AIDS).

Authors:  R C Gallo; P S Sarin; E P Gelmann; M Robert-Guroff; E Richardson; V S Kalyanaraman; D Mann; G D Sidhu; R E Stahl; S Zolla-Pazner; J Leibowitch; M Popovic
Journal:  Science       Date:  1983-05-20       Impact factor: 47.728

8.  Kappa B-specific DNA binding proteins: role in the regulation of human interleukin-2 gene expression.

Authors:  B Hoyos; D W Ballard; E Böhnlein; M Siekevitz; W C Greene
Journal:  Science       Date:  1989-04-28       Impact factor: 47.728

9.  Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS).

Authors:  F Barré-Sinoussi; J C Chermann; F Rey; M T Nugeyre; S Chamaret; J Gruest; C Dauguet; C Axler-Blin; F Vézinet-Brun; C Rouzioux; W Rozenbaum; L Montagnier
Journal:  Science       Date:  1983-05-20       Impact factor: 47.728

10.  The same inducible nuclear proteins regulates mitogen activation of both the interleukin-2 receptor-alpha gene and type 1 HIV.

Authors:  E Böhnlein; J W Lowenthal; M Siekevitz; D W Ballard; B R Franza; W C Greene
Journal:  Cell       Date:  1988-06-03       Impact factor: 41.582
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  3 in total

1.  Syncytium induction in primary CD4+ T-cell lines from normal donors by human immunodeficiency virus type 1 isolates with non-syncytium-inducing genotype and phenotype in MT-2 cells.

Authors:  B J Todd; P Kedar; J H Pope
Journal:  J Virol       Date:  1995-11       Impact factor: 5.103

Review 2.  Interleukin-2 and human immunodeficiency virus infection: pathogenic mechanisms and potential for immunologic enhancement.

Authors:  A Kinter; A S Fauci
Journal:  Immunol Res       Date:  1996       Impact factor: 2.829

3.  Fetal exposure to HIV-1 alters chemokine receptor expression by CD4+T cells and increases susceptibility to HIV-1.

Authors:  Madeleine J Bunders; John L van Hamme; Machiel H Jansen; Kees Boer; Neeltje A Kootstra; Taco W Kuijpers
Journal:  Sci Rep       Date:  2014-10-24       Impact factor: 4.379
  3 in total

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