The tumor suppressor RASSF1A does not interact with Cdc20, an activator of the anaphase-promoting complex.

It has been reported that the RASSF1A tumor suppressor protein controls mitotic progression by binding to and inhibiting Cdc20, an activator of the anaphase-promoting complex. Here, we have used different methods to investigate the association of RASSF1A and Cdc20. We show that there is no interaction between RASSF1A and Cdc20 and conclude that further investigation of the mitotic role of RASSF1A is required.