Literature DB >> 1759855

Evaluation of potential interactions involving trichothecene mycotoxins using the chick embryotoxicity bioassay.

B A Rotter1, B K Thompson, D B Prelusky, H L Trenholm.   

Abstract

The Chick Embryotoxicity Screening Test (CHEST) was used to examine possible interactions between different trichothecenes. Combinations of deoxynivalenol (DON), 15-acetyldeoxynivalenol (15-ADON) and HT-2 toxin were tested at various concentrations and the effects were determined based on percent mortality. The combined toxicity of any two trichothecenes was found to be additive. Discrepancies between observed and expected mortality values seldom differed by more than 10%, well within sampling error for the binomial distribution. Several limitations of the CHEST assay are discussed.

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Year:  1991        PMID： 1759855     DOI： 10.1007/bf01183886

Source DB:  PubMed          Journal:  Arch Environ Contam Toxicol        ISSN： 0090-4341            Impact factor:   2.804


  9 in total

1.  Statistical modeling of the effects of drug combinations.

Authors:  J L Plummer; T G Short
Journal:  J Pharmacol Methods       Date:  1990-07

2.  A series of normal stages in the development of the chick embryo.

Authors:  V HAMBURGER; H L HAMILTON
Journal:  J Morphol       Date:  1951-01       Impact factor: 1.804

3.  Optimization of chick embryotoxicity bioassay for testing toxicity potential of fungal metabolites.

Authors:  D B Prelusky; R M Hamilton; B C Foster; H L Trenholm; B K Thompson
Journal:  J Assoc Off Anal Chem       Date:  1987 Nov-Dec

4.  Toxic synergism between aflatoxin and T-2 toxin in broiler chickens.

Authors:  W E Huff; R B Harvey; L F Kubena; G E Rottinghaus
Journal:  Poult Sci       Date:  1988-10       Impact factor: 3.352

5.  Toxic effects of ochratoxin A and citrinin, alone and in combination, on chicken embryos.

Authors:  D Veselá; D Veselý; R Jelínek
Journal:  Appl Environ Microbiol       Date:  1983-01       Impact factor: 4.792

6.  Individual and combined effects of aflatoxin and deoxynivalenol (DON, vomitoxin) in broiler chickens.

Authors:  W E Huff; L F Kubena; R B Harvey; W M Hagler; S P Swanson; T D Phillips; C R Creger
Journal:  Poult Sci       Date:  1986-07       Impact factor: 3.352

7.  Feeding trials with vomitoxin (deoxynivalenol)-contaminated wheat: effects on swine, poultry, and dairy cattle.

Authors:  H L Trenholm; R M Hamilton; D W Friend; B K Thompson; K E Hartin
Journal:  J Am Vet Med Assoc       Date:  1984-09-01       Impact factor: 1.936

8.  Individual and combined toxicity of deoxynivalenol and T-2 toxin in broiler chicks.

Authors:  L F Kubena; W E Huff; R B Harvey; T D Phillips; G E Rottinghaus
Journal:  Poult Sci       Date:  1989-05       Impact factor: 3.352

Review 9.  Worldwide occurrence of mycotoxins in foods and feeds--an update.

Authors:  C F Jelinek; A E Pohland; G E Wood
Journal:  J Assoc Off Anal Chem       Date:  1989 Mar-Apr
  9 in total
  1 in total

1.  Levels of five mycotoxins in grains harvested in Atlantic Canada as measured by high performance liquid chromatography.

Authors:  G W Stratton; A R Robinson; H C Smith; L Kittilsen; M Barbour
Journal:  Arch Environ Contam Toxicol       Date:  1993-04       Impact factor: 2.804
  1 in total

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