| Literature DB >> 17597786 |
Abstract
A robust inflammatory response involving tumor necrosis factor-alpha (TNF-alpha) is induced during cisplatin nephrotoxicity. Using chimeric models, Reeves and colleagues now demonstrate that resident kidney cells, rather than infiltrating immune cells, are the major producers of TNF-alpha. Blockade of TNF-alpha attenuates inflammation and associated kidney injury.Entities:
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Year: 2007 PMID: 17597786 DOI: 10.1038/sj.ki.5002320
Source DB: PubMed Journal: Kidney Int ISSN: 0085-2538 Impact factor: 10.612