Literature DB >> 17597506

Inhibitory effect of dauricine on inflammatory process following focal cerebral ischemia/reperfusion in rats.

Xiao-Yan Yang1, Shi-Qin Jiang, Li Zhang, Qiang-Ni Liu, Pei-Li Gong.   

Abstract

Our previous experimental studies showed that dauricine could protect the brain from ischemic damage, but the underlying mechanisms were unknown. In this study, we investigated the effect of dauricine on the changes of the inflammation process induced by ischemia/reperfusion (I/R). After I/R, the enzyme activity of MPO, the expression of ICAM-1 and the transcription of IL-1beta and TNF-alpha mRNA were all significantly increased (p < 0.01). And after treatment with dauricine, they were all significantly reduced compared to the vehicle-treated I/R group (p < 0.05 or p < 0.01). These results suggest that dauricin attenuates the inflammation process induced by I/R. The neuroprotective effect of dauricine may partly due to the inhibition acute inflammation induced by I/R.

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Year:  2007        PMID： 17597506     DOI： 10.1142/S0192415X07004990

Source DB:  PubMed          Journal:  Am J Chin Med        ISSN： 0192-415X            Impact factor:   4.667


  9 in total

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  9 in total

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