| Literature DB >> 17597205 |
C Economopoulou1, V Pappa, F Kontsioti, S Papageorgiou, V Kapsimali, C Papasteriadi, P Economopoulou, E Papageorgiou, J Dervenoulas, T Economopoulos.
Abstract
The aim of the present study was to examine caspases, granzyme B and bcl-2 family mRNA expression and the degree of apoptosis in the bone marrow (BM) of 46 Myelodysplastic Syndromes (MDS) and to correlate our findings with clinical parameters. The degree of apoptosis was determined by Annexin V, whereas expression of genes was determined using a multiprobe RNase Protection System. A positive correlation was found between caspases 8, 5, 3, 2, 1 and the level of apoptosis. bfl1 and mcl1 levels were significantly higher in patients with BM blasts >5%. Cases with ratio of bid expression >1 compared to normal pool were associated with IPSS values < or =1.Entities:
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Year: 2007 PMID： 17597205 DOI： 10.1016/j.leukres.2007.04.012
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156