Evaluation of antidiabetic activity of Coldenia procumbens in alloxan-induced diabetes in rat.

Diabetes was induced in Groups II, III and IV rats by alloxan monohydrate at the rate of 180 mg/kg body weight. Body weight increased significantly (p < 0.05) after Coldenia procumbens treatment. Treatment with C. procumbens significantly (p < 0.05) reduced the blood glucose level from 394.17 +/- 10.52 (mg/dl) to 152.83 +/- 2.15 (mg/dl) in rats when compared with diabetic control group of rats. Serum triglyceride levels decreased significantly (p < 0.05) from 152.33 +/- 2.75 (mg/dl) to 109.17 +/- 1.74 (mg/dl) in C. procumbens-treated rats. Treatment with C. procumbens significantly (p < 0.05) reduced the serum cholesterol level from 59.83 +/- 1.01 (mg/dl) to 44.33 +/- 1.96 (mg/dl) in rats. The analysis of data indicates that the test drug has good hypoglycemic effect in diabetic rats.