Literature DB >> 17594529

Position independent and copy-number-related expression of the bovine neonatal Fc receptor alpha-chain in transgenic mice carrying a 102 kb BAC genomic fragment.

Balázs Bender1, Lilla Bodrogi, Balázs Mayer, Zita Schneider, Yaofeng Zhao, Lennart Hammarström, André Eggen, Imre Kacskovics, Zsuzsanna Bosze.   

Abstract

We generated and characterized transgenic mice carrying a 102 kb bovine genomic fragment, encoding the neonatal Fc receptor alpha-chain (bFcRn). FcRn plays a crucial role in the maternal IgG transport and it also regulates the IgG and albumin homeostasis. Some of its functions and transcriptional regulation show species specific differences. The FcRn heterodimer is composed of the alpha-chain and beta-2-microglobulin (beta2 m). A bacterial artificial chromosome containing the bovine FcRn alpha-chain gene (bFCGRT) with its 44 kb 5' and 50 kb long 3' flanking sequences was microinjected into fertilized mouse oocytes. Two of the transgenic lines generated, showed copy number related and integration site independent bFcRn expression. The bFcRn alpha-chain forms a functional receptor with the mouse beta2-microglobulin and extends the half-life of the mouse IgG in transgenic mice. Our results underline the feasibility of creating BAC transgenic mouse models of economically important bovine genes.

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Year:  2007        PMID： 17594529     DOI： 10.1007/s11248-007-9108-9

Source DB:  PubMed          Journal:  Transgenic Res        ISSN： 0962-8819            Impact factor:   2.788


  53 in total

Review 1.  Antibody pharmacokinetics and pharmacodynamics.

Authors:  Evelyn D Lobo; Ryan J Hansen; Joseph P Balthasar
Journal:  J Pharm Sci       Date:  2004-11       Impact factor: 3.534

2.  Expression of the neonatal Fc receptor (FcRn) in the bovine mammary gland.

Authors:  Balázs Mayer; Márton Doleschall; Balázs Bender; János Bartyik; Zsuzsanna Bosze; László V Frenyó; Imre Kacskovics
Journal:  J Dairy Res       Date:  2005       Impact factor: 1.904

3.  Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria.

Authors:  Masaru Yoshida; Kanna Kobayashi; Timothy T Kuo; Lynn Bry; Jonathan N Glickman; Steven M Claypool; Arthur Kaser; Takashi Nagaishi; Darren E Higgins; Emiko Mizoguchi; Yoshio Wakatsuki; Derry C Roopenian; Atsushi Mizoguchi; Wayne I Lencer; Richard S Blumberg
Journal:  J Clin Invest       Date:  2006-08       Impact factor: 14.808

Review 4.  Transgenic modification of cows milk for value-added processing.

Authors:  K A Zuelke
Journal:  Reprod Fertil Dev       Date:  1998       Impact factor: 2.311

5.  An Fc receptor structurally related to MHC class I antigens.

Authors:  N E Simister; K E Mostov
Journal:  Nature       Date:  1989-01-12       Impact factor: 49.962

6.  Position-independent and copy-number-related expression of a goat bacterial artificial chromosome alpha-lactalbumin gene in transgenic mice.

Authors:  M G Stinnakre; S Soulier; L Schibler; L Lepourry; J C Mercier; J L Vilotte
Journal:  Biochem J       Date:  1999-04-01       Impact factor: 3.857

7.  Redistribution of the sheep neonatal Fc receptor in the mammary gland around the time of parturition in ewes and its localization in the small intestine of neonatal lambs.

Authors:  Balázs Mayer; Anna Zolnai; László V Frenyó; Veronika Jancsik; Zoltán Szentirmay; Lennart Hammarström; Imre Kacskovics
Journal:  Immunology       Date:  2002-11       Impact factor: 7.397

8.  Functional reconstitution of human FcRn in Madin-Darby canine kidney cells requires co-expressed human beta 2-microglobulin.

Authors:  Steven M Claypool; Bonny L Dickinson; Masaru Yoshida; Wayne I Lencer; Richard S Blumberg
Journal:  J Biol Chem       Date:  2002-05-22       Impact factor: 5.157

9.  The MHC class I-like IgG receptor controls perinatal IgG transport, IgG homeostasis, and fate of IgG-Fc-coupled drugs.

Authors:  Derry C Roopenian; Gregory J Christianson; Thomas J Sproule; Aaron C Brown; Shreeram Akilesh; Nadja Jung; Stefka Petkova; Lia Avanessian; Eun Young Choi; Daniel J Shaffer; Peter A Eden; Clark L Anderson
Journal:  J Immunol       Date:  2003-04-01       Impact factor: 5.422

10.  Abnormally short serum half-lives of IgG in beta 2-microglobulin-deficient mice.

Authors:  V Ghetie; J G Hubbard; J K Kim; M F Tsen; Y Lee; E S Ward
Journal:  Eur J Immunol       Date:  1996-03       Impact factor: 5.532
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  12 in total

Review 1.  Recent advances using FcRn overexpression in transgenic animals to overcome impediments of standard antibody technologies to improve the generation of specific antibodies.

Authors:  Imre Kacskovics; Judit Cervenak; Anna Erdei; Richard A Goldsby; John E Butler
Journal:  MAbs       Date:  2011-09-01       Impact factor: 5.857

2.  Tissue expression profile of human neonatal Fc receptor (FcRn) in Tg32 transgenic mice.

Authors:  Yao-Yun Fan; Lindsay B Avery; Mengmeng Wang; Denise M O'Hara; Sheldon Leung; Hendrik Neubert
Journal:  MAbs       Date:  2016-04-22       Impact factor: 5.857

3.  FcRn overexpression in mice results in potent humoral response against weakly immunogenic antigen.

Authors:  Attila Végh; Judit Cervenak; István Jankovics; Imre Kacskovics
Journal:  MAbs       Date:  2011-03-01       Impact factor: 5.857

4.  NFκB induces overexpression of bovine FcRn: a novel mechanism that further contributes to the enhanced immune response in genetically modified animals carrying extra copies of FcRn.

Authors:  Judit Cervenak; Márton Doleschall; Balázs Bender; Balázs Mayer; Zita Schneider; Zoltán Doleschall; Yaofeng Zhao; Zsuzsanna Bősze; Lennart Hammarström; Wolfgang Oster; Imre Kacskovics
Journal:  MAbs       Date:  2013 Nov-Dec       Impact factor: 5.857

5.  Influence of FCGRT gene polymorphisms on pharmacokinetics of therapeutic antibodies.

Authors:  Christophe Passot; Nicolas Azzopardi; Sylvaine Renault; Nadine Baroukh; Christophe Arnoult; Marc Ohresser; Michèle Boisdron-Celle; Erick Gamelin; Hervé Watier; Gilles Paintaud; Valérie Gouilleux-Gruart
Journal:  MAbs       Date:  2013-04-25       Impact factor: 5.857

6.  Characterization of the rabbit neonatal Fc receptor (FcRn) and analyzing the immunophenotype of the transgenic rabbits that overexpresses FcRn.

Authors:  Ana Paula Catunda Lemos; Judit Cervenak; Balázs Bender; Orsolya Ivett Hoffmann; Mária Baranyi; Andrea Kerekes; Anita Farkas; Zsuzsanna Bosze; László Hiripi; Imre Kacskovics
Journal:  PLoS One       Date:  2012-01-11       Impact factor: 3.240

Review 7.  Perspectives on immunoglobulins in colostrum and milk.

Authors:  Walter L Hurley; Peter K Theil
Journal:  Nutrients       Date:  2011-04-14       Impact factor: 5.717

8.  FcRn overexpression in transgenic mice results in augmented APC activity and robust immune response with increased diversity of induced antibodies.

Authors:  Attila Végh; Anita Farkas; Dorottya Kövesdi; Krisztián Papp; Judit Cervenak; Zita Schneider; Balázs Bender; László Hiripi; Glória László; József Prechl; János Matkó; Imre Kacskovics
Journal:  PLoS One       Date:  2012-04-30       Impact factor: 3.240

9.  Overexpression of Bovine FcRn in Mice Enhances T-Dependent Immune Responses by Amplifying T Helper Cell Frequency and Germinal Center Enlargement in the Spleen.

Authors:  Zita Schneider; Péter Károly Jani; Bence Szikora; Attila Végh; Dorottya Kövesdi; Attila Iliás; Judit Cervenak; Péter Balogh; István Kurucz; Imre Kacskovics
Journal:  Front Immunol       Date:  2015-07-20       Impact factor: 7.561

10.  Transgenic rabbits that overexpress the neonatal Fc receptor (FcRn) generate higher quantities and improved qualities of anti-thymocyte globulin (ATG).

Authors:  Mária Baranyi; Judit Cervenak; Balázs Bender; Imre Kacskovics
Journal:  PLoS One       Date:  2013-10-23       Impact factor: 3.240
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