OBJECTIVES: The use of patient-based outcomes to measure therapeutic effectiveness is increasing, because a growing number of clinical scientists are attempting to evaluate the impact of therapy on the recipient. There are indications that patients suffering from temporomandibular disorders (TMDs) may also show a reduced oral health-related quality of life (OHQoL). It was the purpose of this paper to answer the question as to whether therapeutic interventions in TMD patients have a positive effect on their OHQoL. MATERIAL AND METHODS: A systematic electronic search (Ovid Medline 1966-2006; Science Citation Index 1945-2006) of the literature was carried out to identify pertinent articles of randomized and non-randomized clinical trials. Reports on retrospective and prospective studies that specifically focused on OHQoL changes in TMD patients as a consequence of therapeutic interventions were included. The reference lists of the identified articles were screened to find additional pertinent publications. RESULTS: The investigation yielded seven relevant contributions from Medline. A quantitative analysis of the seven identified articles was not possible. There was considerable heterogeneity among the investigations with regard to study design, patient characteristics, and provided therapy. Three of the identified articles reported about prospective controlled studies, of which one was an RCT. Four additional investigations were retrospective. According to the results of the only RCT, a 6-week course of the non-selective cyclooxygenase (COX) inhibitor naproxen may lead to slightly better OHQoL in patients with temporomandibular joint (TMJ) arthralgia than the selective COX-2 inhibitor celecoxib. The two other articles reporting of a controlled study showed that selective serotonine uptake inhibitors accompanied by psychological therapy improved OHQoL in individuals with TMJ arthralgia. In contrast, TMJ surgery did not improve OHQoL. CONCLUSION: It appears that all therapeutic interventions reported in the identified publications led to at least some improvement of OHQoL. The only exception were patients with multiple TMJ surgeries.
OBJECTIVES: The use of patient-based outcomes to measure therapeutic effectiveness is increasing, because a growing number of clinical scientists are attempting to evaluate the impact of therapy on the recipient. There are indications that patients suffering from temporomandibular disorders (TMDs) may also show a reduced oral health-related quality of life (OHQoL). It was the purpose of this paper to answer the question as to whether therapeutic interventions in TMDpatients have a positive effect on their OHQoL. MATERIAL AND METHODS: A systematic electronic search (Ovid Medline 1966-2006; Science Citation Index 1945-2006) of the literature was carried out to identify pertinent articles of randomized and non-randomized clinical trials. Reports on retrospective and prospective studies that specifically focused on OHQoL changes in TMDpatients as a consequence of therapeutic interventions were included. The reference lists of the identified articles were screened to find additional pertinent publications. RESULTS: The investigation yielded seven relevant contributions from Medline. A quantitative analysis of the seven identified articles was not possible. There was considerable heterogeneity among the investigations with regard to study design, patient characteristics, and provided therapy. Three of the identified articles reported about prospective controlled studies, of which one was an RCT. Four additional investigations were retrospective. According to the results of the only RCT, a 6-week course of the non-selective cyclooxygenase (COX) inhibitor naproxen may lead to slightly better OHQoL in patients with temporomandibular joint (TMJ) arthralgia than the selective COX-2 inhibitor celecoxib. The two other articles reporting of a controlled study showed that selective serotonine uptake inhibitors accompanied by psychological therapy improved OHQoL in individuals with TMJ arthralgia. In contrast, TMJ surgery did not improve OHQoL. CONCLUSION: It appears that all therapeutic interventions reported in the identified publications led to at least some improvement of OHQoL. The only exception were patients with multiple TMJ surgeries.
Authors: Mariana Moreira da Silva; Regiane Albertini; Ernesto Cesar Pinto Leal-Junior; Paulo de Tarso Camillo de Carvalho; José Antonio Silva; Sandra Kalil Bussadori; Luis Vicente Franco de Oliveira; Cezar Augusto Souza Casarin; Erinaldo Luiz Andrade; Danilo Sales Bocalini; Andrey Jorge Serra Journal: Trials Date: 2015-06-04 Impact factor: 2.279
Authors: Carolina Marciela Herpich; Ernesto Cesar Pinto Leal-Junior; Ana Paula Amaral; Juliana de Paiva Tosato; Igor Phillip dos Santos Glória; Marília Barbosa Santos Garcia; Bruno Roberto Borges Barbosa; Yasmin El Hage; Éric Edmur Camargo Arruda; Cid Ándre Fidelis de Paula Gomes; Monique Sampaio Rodrigues; Dowglas Fernando Magalhães de Sousa; Paulo de Tarso Camillo de Carvalho; Sandra Kalil Bussadori; Tabajara de Oliveira Gonzalez; Fabiano Politti; Daniela Aparecida Biasotto-Gonzalez Journal: Trials Date: 2014-12-16 Impact factor: 2.279