Literature DB >> 17592504

Divergence of hypertrophic growth and fetal gene profile: the influence of beta-blockers.

X-J Du1.   

Abstract

While the expression patterns of cardiac hypertrophy-related genes have been well documented and widely used as markers for hypertrophy, recent research has revealed uncoupling of hypertrophy-related gene profiles and hypertrophic growth. The role of beta-adrenergic signalling in the development of hypertrophy is incompletely understood. The finding of an upregulated expression of hypertrophy-related genes but a suppressed hypertrophy following beta-blockade reveals previously unrecognized sympatho-adrenergic mechanisms of hypertrophic growth.

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Year:  2007        PMID： 17592504      PMCID： PMC1978264          DOI： 10.1038/sj.bjp.0707353

Source DB:  PubMed          Journal:  Br J Pharmacol        ISSN： 0007-1188            Impact factor:   8.739


  26 in total

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8.  Propranolol causes a paradoxical enhancement of cardiomyocyte foetal gene response to hypertrophic stimuli.

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5.  Knockout of beta(1)- and beta(2)-adrenoceptors attenuates pressure overload-induced cardiac hypertrophy and fibrosis.

Authors:  H Kiriazis; K Wang; Q Xu; X-M Gao; Z Ming; Y Su; X-L Moore; G Lambert; M E Gibbs; A M Dart; X-J Du
Journal:  Br J Pharmacol       Date:  2008-01-14       Impact factor: 8.739

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10.  TGR5 activation ameliorates hyperglycemia-induced cardiac hypertrophy in H9c2 cells.

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